BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis.
BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis.
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BRI1 和 BAK1 与 G 蛋白相互作用并调节拟南芥糖响应性生长和发育
DOI：
10.1038/s41467-018-03884-8
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发表时间：
2018-04-18
影响因子：
16.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Peng Y;Chen L;Li S;Zhang Y;Xu R;Liu Z;Liu W;Kong J;Huang X;Wang Y;Cheng B;Zheng L;Li Y
糖作为信号分子调节植物、酵母和动物的生长、发育和基因表达。糖可利用性与植物激素信号的协调对植物生长发育至关重要。糖可利用性和激素依赖性植物生长之间的分子联系在很大程度上是未知的。在这里，我们报道了BRI1和BAK1参与糖响应性生长和发育。葡萄糖以浓度依赖的方式影响BRI1和BAK1的物理相互作用和磷酸化。BRI1和BAK1与介导糖信号的G蛋白相互作用。生化数据表明，BRI1可磷酸化G蛋白β亚基和γ亚基，BAK1可磷酸化G蛋白γ亚基。遗传分析表明，BRI1和BAK1与g蛋白亚基在一个共同的途径中调节糖反应。因此，我们的发现揭示了BR受体与G蛋白结合调控糖响应性生长和发育的重要遗传和分子机制。
Sugars function as signal molecules to regulate growth, development, and gene expression in plants, yeasts, and animals. A coordination of sugar availability with phytohormone signals is crucial for plant growth and development. The molecular link between sugar availability and hormone-dependent plant growth are largely unknown. Here we report that BRI1 and BAK1 are involved in sugar-responsive growth and development. Glucose influences the physical interactions and phosphorylations of BRI1 and BAK1 in a concentration-dependent manner. BRI1 and BAK1 physically interact with G proteins that are essential for mediating sugar signaling. Biochemical data show that BRI1 can phosphorylate G protein β subunit and γ subunits, and BAK1 can phosphorylate G protein γ subunits. Genetic analyses suggest that BRI1 and BAK1 function in a common pathway with G-protein subunits to regulate sugar responses. Thus, our findings reveal an important genetic and molecular mechanism by which BR receptors associate with G proteins to regulate sugar-responsive growth and development.
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影响因子：
64.8
作者：
Chinchilla, Delphine;Zipfel, Cyril;Boller, Thomas
通讯作者：
Boller, Thomas
影响因子：
64.5
作者：
Li, J;Wen, JQ;Walker, JC
通讯作者：
Walker, JC
DOI：
10.1073/pnas.0704751104
发表时间：
2007-10-30
影响因子：
11.1
作者：
Johnston, Christopher A.;Taylor, J. Philip;Willard, Francis S.
通讯作者：
Willard, Francis S.
影响因子：
14.8
作者：
Irani, Niloufer G.;Di Rubbo, Simone;Russinova, Eugenia
通讯作者：
Russinova, Eugenia
影响因子：
3.5
作者：
Grigston, Jeffery C.;Osuna, Daniel;Scheible, Wolf-Ruediger;Liu, Chenggang;Stitt, Mark;Jones, Alan M.
通讯作者：
Jones, Alan M.