Leishmaniasis worldwide and global estimates of its incidence.
Leishmaniasis worldwide and global estimates of its incidence.
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DOI：
10.1371/journal.pone.0035671
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
WHO Leishmaniasis Control Team
中科院分区：
文献类型：
--
作者：
Alvar J;Vélez ID;Bern C;Herrero M;Desjeux P;Cano J;Jannin J;den Boer M;WHO Leishmaniasis Control Team
作为世界卫生组织领导的更新利什曼病经验证据基础的努力的一部分，各国专家提供了过去5年的利什曼病病例数据以及各自国家的治疗和控制信息，并对98个国家和3个地区的利什曼病出版物进行了全面的文献审查（参见“利什曼病国家概况文本S1、S2、S3、S4、S5、S6、S7、S8、S9、S10、S11、S12、S13、S14、S15、S16、S17、S18、S19、S20、S21、S22、S23、S24、S25、S26、S27，S28、S29、S30、S31、S32、S33、S34、S35、S36、S37、S38、S39、S40、S41、S42、S43、S44、S45、S46、S47、S48、S49、S50、S51、S52、S53、S54、S55、S56、S57、S58、S59、S60、S61、S62，S63、S64、S65、S66、S67、S68、S69、S70、S71、S72、S73、S74、S75、S76、S77、S78、S79、S80、S81、S82、S83、S84、S85、S86、S87、S88、S89、S90、S91、S92、S93、S94、S95、S96、S97，S98、S99、S100、S101 '）。在2007年至2011年期间在世卫组织区域一级举行的会议上整理了更多信息。专家和国家方案管理人员完成了关于流行病学和药物获取的两份调查问卷。内脏和皮肤利什曼病的发病率范围是根据报告的发病率、漏报率（如有）以及国家和国际专家的判断按国家和流行病学地区估计的。根据这些估计，每年分别发生约0.2至0.4例VL和CL病例和0.7至120万例。全球90%以上的VL病例发生在六个国家：印度、孟加拉国、苏丹、南苏丹、埃塞俄比亚和巴西。皮肤利什曼病分布更广，约三分之一的病例发生在三个流行区域，即美洲、地中海盆地和从中东到中亚的西亚。估计病例数最高的10个国家，阿富汗、阿尔及利亚、哥伦比亚、巴西、伊朗、叙利亚、埃塞俄比亚、北苏丹、哥斯达黎加和秘鲁，合计占全球估计CL发病率的70 - 75%。死亡率数据非常稀少，通常仅代表医院死亡。使用10%的总病死率，我们初步估计每年有20，000至40，000例利什曼病死亡。虽然一些国家的信息非常贫乏，但这是第一次深入评估利什曼病的真实的影响。这些数据应有助于确定控制策略和加强利什曼病的宣传。
As part of a World Health Organization-led effort to update the empirical evidence base for the leishmaniases, national experts provided leishmaniasis case data for the last 5 years and information regarding treatment and control in their respective countries and a comprehensive literature review was conducted covering publications on leishmaniasis in 98 countries and three territories (see ‘Leishmaniasis Country Profiles Text S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, S13, S14, S15, S16, S17, S18, S19, S20, S21, S22, S23, S24, S25, S26, S27, S28, S29, S30, S31, S32, S33, S34, S35, S36, S37, S38, S39, S40, S41, S42, S43, S44, S45, S46, S47, S48, S49, S50, S51, S52, S53, S54, S55, S56, S57, S58, S59, S60, S61, S62, S63, S64, S65, S66, S67, S68, S69, S70, S71, S72, S73, S74, S75, S76, S77, S78, S79, S80, S81, S82, S83, S84, S85, S86, S87, S88, S89, S90, S91, S92, S93, S94, S95, S96, S97, S98, S99, S100, S101’). Additional information was collated during meetings conducted at WHO regional level between 2007 and 2011. Two questionnaires regarding epidemiology and drug access were completed by experts and national program managers. Visceral and cutaneous leishmaniasis incidence ranges were estimated by country and epidemiological region based on reported incidence, underreporting rates if available, and the judgment of national and international experts. Based on these estimates, approximately 0.2 to 0.4 cases and 0.7 to 1.2 million VL and CL cases, respectively, occur each year. More than 90% of global VL cases occur in six countries: India, Bangladesh, Sudan, South Sudan, Ethiopia and Brazil. Cutaneous leishmaniasis is more widely distributed, with about one-third of cases occurring in each of three epidemiological regions, the Americas, the Mediterranean basin, and western Asia from the Middle East to Central Asia. The ten countries with the highest estimated case counts, Afghanistan, Algeria, Colombia, Brazil, Iran, Syria, Ethiopia, North Sudan, Costa Rica and Peru, together account for 70 to 75% of global estimated CL incidence. Mortality data were extremely sparse and generally represent hospital-based deaths only. Using an overall case-fatality rate of 10%, we reach a tentative estimate of 20,000 to 40,000 leishmaniasis deaths per year. Although the information is very poor in a number of countries, this is the first in-depth exercise to better estimate the real impact of leishmaniasis. These data should help to define control strategies and reinforce leishmaniasis advocacy.
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DOI：
10.4269/ajtmh.2003.69.624
发表时间：
2003-12-01
影响因子：
3.3
作者：
Ahluwalia, IB;Bern, C;Maguire, JH
通讯作者：
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DOI：
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2005-10-01
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影响因子：
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影响因子：
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作者：
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DOI：
10.4269/ajtmh.1990.43.257
发表时间：
1990-09-01
影响因子：
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作者：
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