Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with it
Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with it
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缓解恐惧——走向新的概念框架以及内源性大麻素的作用
DOI：
10.1016/j.neuroscience.2011.11.057
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发表时间：
2012
期刊：
影响因子：
3.3
通讯作者：
C. Wotjak
中科院分区：
文献类型：
--
作者：
C. J. Riebe;F. Pamplona;K. Kamprath;C. Wotjak
内源性大麻素系统似乎在恐惧消除中发挥着非常特殊的作用，这只能在各种恐惧缓解过程的明确模型中进行描述。因此，我们寻求在经典和操作性恐惧调节范式中阐明当前的恐惧缓解概念框架，并在必要时在此框架内提出新的澄清。根据这些修订以及之前涉及内源性大麻素系统和恐惧缓解的研究，我们能够查明内源性大麻素似乎发挥重要作用的过程。在听觉提示的恐惧调节之后，这尤其适用于习惯化及其参与急性和持久的恐惧缓解。相反，在情境调节之后，内源性大麻素似乎也会影响再学习过程。此外，我们描述了内源性大麻素系统在恐惧缓解过程中的参与如何发展，以及这对于临床使用针对内源性大麻素系统的药物疗法治疗恐惧和焦虑症可能意味着什么。本文是题为“压力、情绪行为和内源性大麻素系统”的特刊的一部分。
The endocannabinoid system seems to play very specific roles in fear extinction, which can only be described within a well-defined model of the various fear relief processes. We, therefore, seek to clarify the current conceptual framework of fear relief within classical and operant fear conditioning paradigms as well as propose new clarifications within this framework where necessary. Based on these revisions as well as previous research involving the endocannabinoid system and fear relief, we are able to pinpoint the processes in which endocannabinoids seem to play a significant role. Following auditory-cued fear conditioning, this applies in particular to habituation and its involvement in acute and long-lasting fear relief. Following contextual conditioning, in contrast, endocannabinoids seem to affect relearning processes as well. Furthermore, we describe how the involvement of the endocannabinoid system develops over the course of the fear relief process and what this may imply for the clinical use of pharmacotherapies targeting the endocannabinoid system in treating fear and anxiety disorders. This article is part of a Special Issue entitled: Stress, Emotional Behavior and the Endocannabinoid System.
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DOI：
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发表时间：
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期刊：
--
影响因子：
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作者：
通讯作者：
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影响因子：
7.6
作者：
Kamprath, Kornelia;Romo-Parra, Hector;Pape, Hans-Christian
通讯作者：
Pape, Hans-Christian
影响因子：
2.5
作者：
HUERTA, MF;KAAS, JH
通讯作者：
KAAS, JH
影响因子：
34.7
作者：
Sacktor, Todd C.
通讯作者：
Sacktor, Todd C.
影响因子：
33.6
作者：
Pape HC;Pare D
通讯作者：
Pare D