A shared inhibitory circuit for both exogenous and endogenous control of stimulus selection.
A shared inhibitory circuit for both exogenous and endogenous control of stimulus selection.
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DOI：
10.1038/nn.3352
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发表时间：
2013-04
影响因子：
25
通讯作者：
Knudsen, Eric I.
中科院分区：
文献类型：
--
作者：
Mysore, Shreesh P.;Knudsen, Eric I.
大脑通过抑制分散注意力的刺激来控制注意力的机制尚不清楚。我们发现，仓鸮中脑被盖、大细胞峡部核（Imc）单一抑制回路的局灶性可逆失活，消除了视神经顶盖（哺乳动物上丘）中刺激驱动的（外源性）和内部驱动的（内源性）竞争相互作用，这些相互作用对行为动物在干扰物中选择目标至关重要。Imc神经元将空间精确的多感官和内源性输入转化为强大的抑制性输出，抑制整个顶盖空间图上的竞争性表征。我们发现了一个小的，但非常有效的电路，它被外源性和内源性信号所利用，在中脑选择网络中施加竞争抑制。我们的发现首次揭示了构建优先级图的神经机制，该优先级图对于选择最重要的凝视和注意刺激至关重要。
The mechanisms by which the brain suppresses distracting stimuli to control the locus of attention are unknown. We found that focal, reversible inactivation of a single inhibitory circuit in the barn owl midbrain tegmentum, the nucleus isthmi pars magnocellularis (Imc), abolished both stimulus-driven (exogenous) and internally-driven (endogenous) competitive interactions in the optic tectum (superior colliculus in mammals), which are vital to the selection of a target among distracters in behaving animals. Imc neurons transformed spatially precise multisensory and endogenous input into powerful inhibitory output that suppressed competing representations across the entire tectal space map. We identified a small, but highly potent, circuit that is employed by both exogenous and endogenous signals to exert competitive suppression in the midbrain selection network. Our findings reveal, for the first time, a neural mechanism for the construction of a priority map that is critical for the selection of the most important stimulus for gaze and attention.
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