Plasmodium falciparum gametocyte carriage is associated with subsequent Plasmodium vivax relapse after treatment.
Plasmodium falciparum gametocyte carriage is associated with subsequent Plasmodium vivax relapse after treatment.
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DOI：
10.1371/journal.pone.0018716
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发表时间：
2011-04-20
期刊：
影响因子：
3.7
通讯作者：
Fukuda MM
中科院分区：
文献类型：
--
作者：
Lin JT;Bethell D;Tyner SD;Lon C;Shah NK;Saunders DL;Sriwichai S;Khemawoot P;Kuntawunggin W;Smith BL;Noedl H;Schaecher K;Socheat D;Se Y;Meshnick SR;Fukuda MM
恶性疟原虫/间日疟原虫混合感染在东南亚很常见。当恶性疟原虫疟疾患者接受治疗并随访数周时，很大一部分患者将发展为间日疟原虫疟疾。在对柬埔寨西部两项疟疾治疗试验招募的243名患者进行的综合分析中，入院时携带恶性疟原虫配子体的患者中有20/43（47%）在随访第28天发生了间日疟原虫疟疾。初始血涂片上Pf配子母细胞的存在与治疗后间日疟原虫寄生虫血症率增加3.5倍相关（IRR = 3.5，95%CI 2.0-6.0，p<0.001）。 当控制暴露和免疫相关性（如疟疾史、男性和年龄）时，治疗后间日疟原虫感染率持续增加（IRR = 3.0，95% CI 1.9-4.7，p<0.001）。 聚合酶链反应（PCR）证实，在随访期间发生间日疟的受试者中，只有低比例（5/55或9.1%）在基线时外周血中可检出Pv寄生虫。通过逆转录酶PCR对一部分患者的恶性疟原虫配子体进行分子检测，加强了观察到的相关性，而在随访时对Pv寄生虫血症进行PCR检测与显微镜检查结果相似。这些研究结果表明，大多数间日疟感染后产生的治疗恶性疟疾起源于复发的肝脏阶段的寄生虫。在柬埔寨西部等地，急性恶性疟患者血涂片上有性和无性形式的恶性疟原虫的存在可作为可能的隐性间日疟原虫合并感染和随后复发的标志。这些患者可能受益于经验性治疗8-氨基喹诺酮类药物，如伯氨喹。
Mixed P. falciparum/P. vivax infections are common in southeast Asia. When patients with P. falciparum malaria are treated and followed for several weeks, a significant proportion will develop P. vivax malaria. In a combined analysis of 243 patients recruited to two malaria treatment trials in western Cambodia, 20/43 (47%) of those with P. falciparum gametocytes on admission developed P. vivax malaria by Day 28 of follow-up. The presence of Pf gametocytes on an initial blood smear was associated with a 3.5-fold greater rate of vivax parasitemia post-treatment (IRR = 3.5, 95% CI 2.0–6.0, p<0.001). The increased rate of post-treatment P. vivax infection persisted when correlates of exposure and immunity such as a history of malaria, male gender, and age were controlled for (IRR = 3.0, 95% CI 1.9–4.7, p<0.001). Polymerase chain reaction (PCR) confirmed that only a low proportion of subjects (5/55 or 9.1%) who developed vivax during follow-up had detectable Pv parasites in the peripheral blood at baseline. Molecular detection of falciparum gametocytes by reverse transcriptase PCR in a subset of patients strengthened the observed association, while PCR detection of Pv parasitemia at follow-up was similar to microscopy results. These findings suggest that the majority of vivax infections arising after treatment of falciparum malaria originate from relapsing liver-stage parasites. In settings such as western Cambodia, the presence of both sexual and asexual forms of P. falciparum on blood smear at presentation with acute falciparum malaria serves as a marker for possible occult P. vivax coinfection and subsequent relapse. These patients may benefit from empiric treatment with an 8-aminoquinolone such as primaquine.
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DOI：
10.1093/cid/ciq249
发表时间：
2011-03-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Douglas NM;Nosten F;Ashley EA;Phaiphun L;van Vugt M;Singhasivanon P;White NJ;Price RN
通讯作者：
Price RN
DOI：
10.4269/ajtmh.2008.78.442
发表时间：
2008-03-01
影响因子：
3.3
作者：
Bousema, J. Teun;Drakeley, Chris J.;Sauerwein, Robert W.
通讯作者：
Sauerwein, Robert W.
影响因子：
3.7
作者：
Zwang J;Ashley EA;Karema C;D'Alessandro U;Smithuis F;Dorsey G;Janssens B;Mayxay M;Newton P;Singhasivanon P;Stepniewska K;White NJ;Nosten F
通讯作者：
Nosten F
DOI：
10.4269/ajtmh.2002.67.411
发表时间：
2002-10-01
影响因子：
3.3
作者：
McKenzie, FE;Jeffery, GM;Collins, WE
通讯作者：
Collins, WE
影响因子：
4.9
作者：
Noedl, H;Teja-Isavadharm, P;Miller, RS
通讯作者：
Miller, RS