Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.
Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.
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精确合成的分段聚氨酯可实现嵌段序列控制的药物输送
DOI：
10.1039/d1sc06457f
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发表时间：
2022-05-11
期刊：
影响因子：
8.4
通讯作者：
Fu, Qiang
中科院分区：
文献类型：
--
作者：
Song, Yuanqing;Sun, Chuandong;Tian, Chenxu;Ming, Hao;Wang, Yanjun;Liu, Wenkai;He, Nan;He, Xueling;Ding, Mingming;Li, Jiehua;Luo, Feng;Tan, Hong;Fu, Qiang
构建具有序列控制块结构的聚氨酯（pu）仍然是一个严峻的挑战。在这里，我们报道了从市售单体中精确合成具有理想分子量，窄分子量分布和控制块序列的pu。合成程序源自液相合成方法，该方法涉及基于二异氰酸酯的迭代协议与收敛策略相结合。此外，还制备了一对阳离子和阴离子片段序列不同的多功能pu。我们发现，功能片段的序列顺序会影响纳米载体的自组装行为，并导致组装胶束的意想不到的表面电荷，从而影响纳米载体在体内和体外的蛋白质吸收、细胞内化、生物分布和抗肿瘤作用。本工作为结构复杂、功能多样的精确多块pu的开发提供了一个通用的平台，将极大地促进pu在生物医学领域的临床转化。采用精密的合成平台制备了具有不同片段顺序的聚氨酯（pu），功能片段的序列顺序对纳米药物载体的表面电荷和性能起着至关重要的调节作用。
The construction of polyurethanes (PUs) with sequence-controlled block structures remains a serious challenge. Here, we report the precise synthesis of PUs with desirable molecular weight, narrow molecular weight distribution, and controlled block sequences from commercially available monomers. The synthetic procedure is derived from a liquid-phase synthetic methodology, which involves diisocyanate-based iterative protocols in combination with a convergent strategy. Furthermore, a pair of multifunctional PUs with different sequence orders of cationic and anion segments were prepared. We show that the sequence order of functional segments presents an impact on the self-assembly behavior and results in unexpected surface charges of assembled micelles, thereby affecting the protein absorption, cell internalization, biodistribution and antitumor effect of the nanocarriers in vitro and in vivo. This work provides a versatile platform for the development of precise multiblock PUs with structural complexity and functional diversity, and will greatly facilitate the clinical translation of PUs in biomedicine. Polyurethanes (PUs) with different segment sequence orders are prepared using a precise synthetic platform, and the sequence order of functional segments plays a crucial role in regulating the surface charges and performance of nano-drug carriers.
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影响因子：
23.5
作者：
Gunay, Ufuk Saim;Petit, Benoit Eric;Lutz, Jean-Francois
通讯作者：
Lutz, Jean-Francois
氧化引发的胆固醇修饰多肽的构象定向胶束到囊泡的转变
影响因子：
15
作者：
Liu, Hang;Wang, Rui;Fu, Qiang
通讯作者：
Fu, Qiang
DOI：
10.1039/p19950000541
发表时间：
1995-03-07
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
影响因子：
--
作者：
DENHOLM, AA;GEORGE, MH;WIDDOWSON, DA
通讯作者：
WIDDOWSON, DA
影响因子：
6.2
作者：
Hartmann, L;Krause, E;Börner, HG
通讯作者：
Börner, HG
影响因子：
8.4
作者：
Epps, Thomas H., III;O'Reilly, Rachel K.
通讯作者：
O'Reilly, Rachel K.