Lateralized response timing deficits in autism.
Lateralized response timing deficits in autism.
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DOI：
10.1016/j.biopsych.2009.01.008
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发表时间：
2009-08-15
影响因子：
10.6
通讯作者：
Sweeney, John A.
中科院分区：
文献类型：
--
作者：
D'Cruz, Anna-Maria;Mosconi, Matthew W.;Steele, Shelly;Rubin, Leah H.;Luna, Beatriz;Minshew, Nancy;Sweeney, John A.
程序性学习是一种内隐过程，在这种过程中，行为反应通过反复的表现而得到完善。支持这一认知过程的神经系统包括特定的额纹状体系统，负责计划运动反应的准备和定时。评估程序性学习任务的表现可以提供关于神经发育障碍的独特信息，其中额纹状体障碍已被报道，如自闭症。52名自闭症患者和54名年龄、智商和性别匹配的健康人进行了动眼肌系列反应时间任务和感觉运动控制任务。在自闭症患者中，程序性学习的速度和计划运动反应的准确性没有受到损害，但在预测反应的时间方面却出现了侧向改变。与健康对照者相比，自闭症个体向右跳变反应更快。快速向右预测扫视提示自闭症患者左半球纹状体计时系统的非典型功能。
Procedural learning is an implicit process in which a behavioral response is refined through repeated performance. Neural systems supporting this cognitive process include specific frontostriatal systems responsible for the preparation and timing of planned motor responses. Evaluating performance on procedural learning tasks can provide unique information about neurodevelopmental disorders in which frontostriatal disturbances have been reported, such as autism. Fifty-two individuals with autism and 54 age-, IQ-, and gender-matched healthy individuals performed an oculomotor serial reaction time task and a sensorimotor control task. Whereas the rate of procedural learning and the precision of planned motor responses were unimpaired in autism, a lateralized alteration in the ability to time predictive responses was observed. Rightward saccadic responses were speeded in individuals with autism relative to healthy control subjects. Speeded rightward predictive saccades suggest atypical functioning of left hemisphere striatal chronometric systems in autism.
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影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
影响因子：
2.4
作者：
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DOI：
10.1111/j.1469-7610.1997.tb01539.x
发表时间：
1997-07-01
影响因子：
7.6
作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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