Biological Activities and Chemical Composition of Essential Oil from Hedyosmum purpurascens (Todzia)-An Endemic Plant in Ecuador.
Biological Activities and Chemical Composition of Essential Oil from Hedyosmum purpurascens (Todzia)-An Endemic Plant in Ecuador.
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DOI：
10.3390/molecules28052366
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发表时间：
2023-03-04
期刊：
影响因子：
--
通讯作者：
Morocho V
中科院分区：
文献类型：
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作者：
Calva J;Cartuche L;Castillo LN;Morocho V
紫癜Hedyosmum purpurascens是厄瓜多尔安第斯山脉的一种特有物种，其特点是气味宜人。本研究采用Clevenger-type装置，采用水蒸气蒸馏法提取紫癜花紫荆精油（EO）。在DB-5ms和HP-INNOWax两根毛细管柱上，采用GC-MS和GC-FID进行化学成分鉴定。共鉴定出90种化合物，占总化学成分的98%以上。Germacrene-D、ϒ-terpinene、α-茶香烯、sabinene、O-cymene、1,8-桉叶油脑和α-蒎烯占EO组成的59%以上。EO的对映选择分析显示(+)-α-蒎烯为纯对映体；此外，还发现了4对对映体（α-茶树烯、o-花仙花烯、柠檬烯和月桂烯）。对其抗微生物活性、抗氧化剂活性和抗胆碱酯酶性能进行了评价，结果表明，其抗胆碱酯酶活性和抗氧化活性中等，IC50值为95.62±1.03µg/mL， SC50值为56.38±1.96。所有菌株的抑菌效果均较差，MIC值均大于1000µg/mL。结果表明，紫癜菌EO具有较强的抗氧化活性和乙酰胆碱酯酶活性。尽管有这些令人鼓舞的结果，但进一步的研究似乎是必要的，以验证这种药用物种的安全性作为剂量和时间的函数。对其作用机制的实验研究是验证其药理特性的必要条件。
Hedyosmum purpurascens is an endemic species found in the Andes of Ecuador and it is characterized by its pleasant smell. In this study, essential oil (EO) from H. purpurascens was obtained by the hydro-distillation method with a Clevenger-type apparatus. The identification of the chemical composition was carried out by GC–MS and GC–FID in two capillary columns, DB-5ms and HP-INNOWax. A total of 90 compounds were identified, representing more than 98% of the total chemical composition. Germacrene-D, ϒ-terpinene, α-phellandrene, sabinene, O-cymene, 1,8-cineole and α-pinene accounted for more than 59% of the EO composition. The enantioselective analysis of the EO revealed the occurrence of (+)-α-pinene as a pure enantiomer; in addition, four pairs of enantiomers were found (α-phellandrene, o-cymene, limonene and myrcene). The biological activity against microbiological strains and antioxidants and the anticholinesterase properties were also evaluated and the EO showed a moderate anticholinesterase and antioxidant effect, with an IC50 value of 95.62 ± 1.03 µg/mL and a SC50 value of 56.38 ± 1.96. A poor antimicrobial effect was observed for all the strains, with MIC values over 1000 µg/mL. Based on our results, the H. purpurasens EO presented remarkable antioxidant and AChE activities. Despite these promising results, further research seems essential to validate the safety of this medicinal species as a function of dose and time. Experimental studies on the mechanisms of action are essential to validate its pharmacological properties.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
影响因子：
1
作者：
Capetanos, Chrysostomos;Saroglour, Vasiliki;Skaltsa, Helen D.
通讯作者：
Skaltsa, Helen D.
影响因子：
1.7
作者：
Carroll, John F.;Tabanca, Nurhayat;Zhang, Sui
通讯作者：
Zhang, Sui
影响因子：
2.6
作者：
Cozzani, S;Muselli, A;Casanova, J
通讯作者：
Casanova, J
DOI：
10.3390/plants11212832
发表时间：
2022-10-25
期刊：
Plants (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
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