Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.
Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.
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DOI：
10.1038/s41370-022-00443-8
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发表时间：
2023-11
影响因子：
4.5
通讯作者：
Bhatti, Parveen
中科院分区：
文献类型：
--
作者：
Yao, Lena;Liu, Lili;Dong, Ming;Yang, Jinmei;Zhao, Zhiqiang;Chen, Jiabin;Lv, Lijuan;Wu, Zhaoxia;Wang, Jin;Sun, Xin;Self, Steven;Bhatti, Parveen
关于产前接触多种重金属对儿童早期体型和生长的影响的研究有限。我们在一项针对 358 对母子的研究中，评估了 15 种重金属的产前暴露情况，并与出生时以及 1 个月、3 个月和 6 个月时测量的体重、身长和头围 (HC) 指标相关。在妊娠早期和晚期测量尿液浓度，并使用性别分层一般线性模型进行检查，将其与平均标准化尺寸和生命前六个月的尺寸变化（生长）相关联。探讨了金属之间的混杂效应。妊娠早期 Hg 和 V 的增加分别与男性平均 HC 和女性体重降低相关。妊娠早期 V 的增加与女性体重随时间的下降有关。妊娠晚期 Cs、Rb 和 Tl 的增加与男性平均体重和 HC 的增加有关。随着时间的推移，妊娠晚期 Se 的增加与女性 HC 的增加有关。在 Cs、Rb 和 Tl 之间观察到与体重和 HC 相关的混杂证据。我们观察到产前重金属暴露与产后体型和生长之间存在多种生物学上合理的关联。
There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth. We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and one, three and six months of age in a study of 358 mother-child pairs. Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first six months of life. Confounding effects among metals were explored. Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC. We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth.
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影响因子：
3.3
作者：
Fortoul, T. I.;Rojas-Lemus, M.;Altamirano-Lozano, M.
通讯作者：
Altamirano-Lozano, M.
影响因子：
8.3
作者：
Gade M;Comfort N;Re DB
通讯作者：
Re DB
DOI：
10.1186/1476-069x-4-20
发表时间：
2005-10-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Berglund M;Lind B;Björnberg KA;Palm B;Einarsson O;Vahter M
通讯作者：
Vahter M
影响因子：
5.5
作者：
Hofstee, Pierre;Bartho, Lucy A.;Cuffe, James S. M.
通讯作者：
Cuffe, James S. M.
DOI：
10.3390/ijerph17114032
发表时间：
2020-06-01
影响因子：
--
作者：
Baldewsingh, Gaitree K.;Wickliffe, Jeffrey K.;Zijlmans, Wilco C. W. R.
通讯作者：
Zijlmans, Wilco C. W. R.