Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms.
Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms.
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DOI：
10.1016/j.envres.2021.111558
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发表时间：
2021-10
影响因子：
8.3
通讯作者：
Re DB
中科院分区：
文献类型：
--
作者：
Gade M;Comfort N;Re DB
重金属铅（Pb）、汞（Hg）和镉（Cd）是普遍存在的环境污染物，即使浓度很低，也会对神经系统产生严重的不利影响。相比之下，重金属锰（Mn）首先是一种必需的营养素，但它在高水平时会产生神经毒性。神经毒性金属还包括不太普遍的类金属砷，在世界许多地区的饮用水和食物来源中发现砷的浓度过高。男性和女性对环境暴露的反应往往不同，对神经系统的不利影响也不例外。在这里，我们回顾了不同类型的性别特异性神经毒性效应，如认知和运动障碍，已归因于铅，汞，锰，镉和砷暴露在整个生命过程中的流行病学和实验毒理学研究。我们还讨论了对这些金属的不同脆弱性，例如性别行为和职业的差异。最后，我们探讨了假设的不同机制，以解释基于性别的差异易感性，包括激素，遗传，代谢，解剖，神经化学和表观遗传扰动。了解环境重金属神经毒性的性别特异性影响，有助于在与性别相关的易感性和脆弱性方面制定更有效的系统性风险评估方法和更好的缓解接触战略。
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental pollutants and are known to exert severe adverse impacts on the nervous system even at low concentrations. In contrast, the heavy metal manganese (Mn) is first and foremost an essential nutrient, but it becomes neurotoxic at high levels. Neurotoxic metals also include the less prevalent metalloid arsenic (As) which is found in excessive concentrations in drinking water and food sources in many regions of the world. Males and females often differ in how they respond to environmental exposures and adverse effects on their nervous systems are no exception. Here, we review the different types of sex-specific neurotoxic effects, such as cognitive and motor impairments, that have been attributed to Pb, Hg, Mn, Cd, and As exposure throughout the life course in epidemiological as well as in experimental toxicological studies. We also discuss differential vulnerability to these metals such as distinctions in behaviors and occupations across the sexes. Finally, we explore the different mechanisms hypothesized to account for sex-based differential susceptibility including hormonal, genetic, metabolic, anatomical, neurochemical, and epigenetic perturbations. An understanding of the sex-specific effects of environmental heavy metal neurotoxicity can aid in the development of more efficient systematic approaches in risk assessment and better exposure mitigation strategies with regard to sex-linked susceptibilities and vulnerabilities.
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DOI：
10.1056/nejmsr1809937
发表时间：
2019-08-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
All of Us Research Program Investigators;Denny JC;Rutter JL;Goldstein DB;Philippakis A;Smoller JW;Jenkins G;Dishman E
通讯作者：
Dishman E
影响因子：
158.5
作者：
BAGHURST, PA;MCMICHAEL, AJ;TONG, SL
通讯作者：
TONG, SL
DOI：
10.1080/19338244.2015.1129301
发表时间：
2016-01-01
影响因子：
1.8
作者：
Adams, Scott V.;Barrick, Brian;Ulery, April
通讯作者：
Ulery, April
影响因子：
8.3
作者：
Aherrera, Angela;Olmedo, Pablo;Navas-Acien, Ana
通讯作者：
Navas-Acien, Ana
影响因子：
3.5
作者：
Anderson DW;Mettil W;Schneider JS
通讯作者：
Schneider JS