Vestibular effects on cerebral blood flow.
Vestibular effects on cerebral blood flow.
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DOI：
10.1186/1471-2202-10-119
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发表时间：
2009-09-23
期刊：
影响因子：
2.4
通讯作者：
Wood SJ
中科院分区：
文献类型：
--
作者：
Serrador JM;Schlegel TT;Black FO;Wood SJ
人类表现出许多独特的适应性，允许在直立时维持血压和脑血流量。虽然包括大脑自动调节在内的几个生理系统参与了这种适应，但前庭系统在帮助维持脑血流方面的独特作用才刚刚开始阐明。在这项研究中，我们测试了前庭系统的刺激，特别是耳石器官，会导致脑血流量的变化的假设。为了验证我们的假设，我们刺激前庭器官的25名健康受试者的俯仰倾斜（刺激运河和耳石）和平移的离心机（刺激耳石，而不是运河）在五个频率：0.5，0.25，0.125和0.0625赫兹为80秒和0.03125赫兹为160秒。脑血流速度（经颅多普勒）和血压（Finapres）的变化在两种刺激期间相似，并依赖于刺激频率（P < 0.01）。然而，脑血流量的变化与血压的变化相反，并且不完全依赖于潮气末CO2的变化。实验结果支持我们的假设，并提供证据表明，前庭器官，特别是耳石器官的激活，直接影响脑血流调节，独立于血压和潮气末二氧化碳的变化。
Humans demonstrate a number of unique adaptations that allow for the maintenance of blood pressure and brain blood flow when upright. While several physiological systems, including cerebral autoregulation, are involved in this adaptation the unique role the vestibular system plays in helping to maintain brain blood flow is just beginning to be elucidated. In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P < 0.01). However, changes in cerebral blood flow were in opposition to changes in blood pressure and not fully dependent on changes in end tidal CO2. The experimental results support our hypothesis and provide evidence that activation of the vestibular apparatus, specifically the otolith organs, directly affects cerebral blood flow regulation, independent of blood pressure and end tidal CO2 changes.
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影响因子：
2.5
作者：
FERNANDEZ, C;GOLDBERG, JM
通讯作者：
GOLDBERG, JM
影响因子：
3.3
作者：
Poulin, MJ;Liang, PJ;Robbins, PA
通讯作者：
Robbins, PA
DOI：
10.1152/ajpregu.1994.267.4.r974
发表时间：
1994-10-01
影响因子：
2.8
作者：
YATES, BJ;GRELOT, L;MILLER, AD
通讯作者：
MILLER, AD
影响因子：
8.3
作者：
AASLID, R;LINDEGAARD, KF;NORNES, H
通讯作者：
NORNES, H
影响因子：
3.5
作者：
Heckmann, JG;Leis, S;Neundörfer, B
通讯作者：
Neundörfer, B