Treatment with medium chain fatty acids milk of CD36-deficient preschool children.
Treatment with medium chain fatty acids milk of CD36-deficient preschool children.
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用中链脂肪酸奶治疗缺乏 CD36 的学龄前儿童。
DOI：
10.1016/j.nut.2017.11.005
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发表时间：
2018
期刊：
影响因子：
4.4
通讯作者：
Takashi Miida
中科院分区：
文献类型：
--
作者：
Hironori Nagasaka;Ken-ichi Hirano;Tohru Yorifuji;Haruki Komatsu;Tomonozumi Takatani;Ichiro Morioka;Satoshi Hirayama;Takashi Miida
CD 36缺乏症的特征在于骨骼肌和心肌中细胞长链脂肪酸摄取有限，并且经常导致这些肌肉中的能量危机。然而，CD 36缺乏症的合适治疗仍有待建立。本研究的目的是评估中链三酰甘油（MCT）在两个CD 36缺陷的学龄前儿童中的临床和代谢作用，这些儿童经常发生空腹低血糖和运动引起的肌痛。检查并比较了常规晚餐饮食和用2 g/kg含9% MCT的牛奶替代一种组分的饮食的游离脂肪酸（MCT牛奶）。检查并比较了血清肌酸激酶和丙氨酸氨基转移酶水平的变化，这些变化是由1 g/kg MCT牛奶替代葡萄糖水摄入量引起的，并通过使用自行车踏板任务测定。在日常生活中的低血糖和/或肌痛发作也investigated.ResultsBiochemically，参与者的血糖和总酮体水平禁食过夜后，饮食晚餐后，含有MCT牛奶大幅增加。MCT牛奶可抑制自行车踏板任务导致的血清肌酸激酶和丙氨酸氨基转移酶水平升高。在引入含有MCT牛奶的膳食晚餐后，导致早餐前意识不清和心动过速的低血糖减少了。在下肢肌痛的发生也减少摄入MCT牛奶之前长时间和/或剧烈exercising.ConclusionOur结果表明，MCT可以防止空腹低血糖和运动引起的肌痛在CD 36缺陷的幼儿。
ObjectiveCD36 deficiency is characterized by limited cellular long chain fatty acid uptake in the skeletal and cardiac muscles and often causes energy crisis in these muscles. However, suitable treatment for CD36 deficiency remains to be established. The aim of this study was to evaluate the clinical and metabolic effects of medium chain triacylglycerols (MCTs) in two CD36-deficient preschool children who often developed fasting hypoglycemia and exercise-induced myalgia.MethodsFasting blood glucose, total ketone bodies, and free fatty acids were examined and compared for usual supper diets and for diets with replacement of one component with 2 g/kg of 9% MCT–containing milk (MCT milk). Changes in serum creatine kinase and alanine aminotransferase levels, resulting from replacement of glucose water intake with 1 g/kg of MCT milk and determined by using bicycle pedaling tasks, were examined and compared. Hypoglycemic and/or myalgia episodes in daily life were also investigated.ResultsBiochemically, participants' blood glucose and total ketone bodies levels after overnight fasting substantially increased after dietary suppers containing MCT milk. Increases in serum creatine kinase and alanine aminotransferase levels resulting from the bicycle pedaling task were suppressed by MCT milk. Hypoglycemia leading to unconsciousness and tachycardia before breakfast decreased after introduction of dietary suppers containing MCT milk. Occurrence of myalgia in the lower limbs also decreased after intakes of MCT milk before long and/or strenuous exercising.ConclusionOur results suggest that MCTs can prevent fasting hypoglycemia and exercise-induced myalgia in CD36-deficient young children.
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CD36 缺陷 I 型和 II 型的表型-基因型相关性
影响因子：
6.7
作者：
H. Yanai;H. Chiba;H. Fujiwara;M. Morimoto;K. Abe;Shigeru Yoshida;Yukihiro Takahashi;H. Fuda;S. Hui;H. Akita;K. Kobayashi;K. Matsuno
通讯作者：
K. Matsuno
影响因子：
20.3
作者：
N. Yamamoto;N. Akamatsu;Hitoshi Sakuraba;H. Yamazaki;K. Tanoue
通讯作者：
N. Yamamoto;N. Akamatsu;Hitoshi Sakuraba;H. Yamazaki;K. Tanoue
影响因子：
20.3
作者：
D. Greenwalt;Robert Lipsky;C. Ockenhouse;H. Ikeda;N. Tandon;G. Jamieson
通讯作者：
D. Greenwalt;Robert Lipsky;C. Ockenhouse;H. Ikeda;N. Tandon;G. Jamieson
影响因子：
15.9
作者：
KASHIWAGI, H;TOMIYAMA, Y;MATSUZAWA, Y
通讯作者：
MATSUZAWA, Y
儿童特发性自发性低血糖。
影响因子：
8
作者：
J. Haworth;F. J. Coodin
通讯作者：
F. J. Coodin