Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004.
Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004.
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DOI：
10.1001/archinternmed.2008.604
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发表时间：
2009-03-23
影响因子：
--
通讯作者：
Camargo, Carlos A., Jr.
中科院分区：
文献类型：
--
作者：
Ginde, Adit A.;Liu, Mark C.;Camargo, Carlos A., Jr.
维生素 D 不足与健康状况不佳有关。维生素 D 缺乏的患病率可能正在上升，但基于人群的趋势尚不确定。我们试图评估美国人口维生素 D 不足的趋势。我们将 1988 年至 1994 年期间收集的第三次全国健康和营养检查调查 (NHANES III) 的血清 25-羟基维生素 D (25[OH]D) 水平与 2001 年至 2004 年收集的 NHANES 数据 (NHANES 2001-2004) 进行了比较。 NHANES III 中的 18 883 名参与者和 NHANES 2001-2004 中的 13 369 名参与者有完整的数据。在 NHANES III 期间，平均血清 25(OH)D 水平为 30（95% 置信区间 [CI]，29–30）ng/mL，在 NHANES 2001–2004 期间下降至 24（23–25）ng/mL。因此，25(OH)D 水平低于 10 ng/mL 的患病率从 2% (95% CI，2%–2%) 增加到 6% (5%–8%)，25(OH)D 水平为 30 ng/mL 或更高的患病率从 45% (43%–47%) 下降到 23% (20%–26%)。非西班牙裔黑人中 25(OH)D 水平低于 10 ng/mL 的患病率从 NHANES III 期间的 9% 上升到 NHANES 2001-2004 期间的 29%，而 30 ng/mL 或更高水平的患病率相应从 12% 下降到 3%。 NHANES III 期间按年龄层（平均血清 25[OH]D 水平范围为 28–32 ng/mL）和性别（女性 28 ng/mL，男性 32 ng/mL）的差异在 NHANES 2001–2004 期间趋于平衡（年龄 24 ng/mL 与性别 24 ng/mL，性别 24 ng/mL 与 24 ng/mL）。国家数据表明，从 1988-1994 年到 2001-2004 年 NHANES 数据收集期间，血清 25(OH)D 水平显着下降。种族/民族差异一直存在，可能对已知的健康差异产生重要影响。目前关于补充维生素 D 的建议不足以解决日益流行的维生素 D 不足问题。
Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency. We compared serum 25-hydroxyvitamin D (25[OH]D) levels from the Third National Health and Nutrition Examination Survey (NHANES III), collected during 1988 through 1994, with NHANES data collected from 2001 through 2004 (NHANES 2001–2004). Complete data were available for 18 883 participants in NHANES III and 13 369 participants in NHANES 2001–2004. The mean serum 25(OH)D level was 30 (95% confidence interval [CI], 29–30) ng/mL during NHANES III and decreased to 24 (23–25) ng/mL during NHANES 2001–2004. Accordingly, the prevalence of 25(OH)D levels of less than 10 ng/mL increased from 2% (95% CI, 2%–2%) to 6% (5%–8%), and 25(OH)D levels of 30 ng/mL or more decreased from 45% (43%–47%) to 23% (20%–26%). The prevalence of 25(OH)D levels of less than 10 ng/mL in non-Hispanic blacks rose from 9% during NHANES III to 29% during NHANES 2001–2004, with a corresponding decrease in the prevalence of levels of 30 ng/mL or more from 12% to 3%. Differences by age strata (mean serum 25[OH]D levels ranging from 28–32 ng/mL) and sex (28 ng/mL for women and 32 ng/mL for men) during NHANES III equalized during NHANES 2001–2004 (24 vs 24 ng/mL for age and 24 vs 24 ng/mL for sex). National data demonstrate a marked decrease in serum 25(OH)D levels from the 1988–1994 to the 2001–2004 NHANES data collections. Racial/ethnic differences have persisted and may have important implications for known health disparities. Current recommendations for vitamin D supplementation are inadequate to address the growing epidemic of vitamin D insufficiency.
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影响因子：
5.5
作者：
Gorham, Edward D.;Garland, Cedric F.;Holick, Michael F.
通讯作者：
Holick, Michael F.
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Barger-Lux, MJ;Heaney, RP;Holick, MF
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Holick, MF
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168.9
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GARLAND, CF;COMSTOCK, GW;GORHAM, ED
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GORHAM, ED
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Black, PN;Scragg, R
通讯作者：
Scragg, R
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作者：
Forman, John P.;Giovannucci, Edward;Curhan, Gary C.
通讯作者：
Curhan, Gary C.