Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe.
Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe.
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肿瘤相关巨噬细胞的表观遗传修饰：老敌人的新视角
DOI：
10.3389/fimmu.2022.836223
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发表时间：
2022
影响因子：
7.3
通讯作者：
Qiao Y
中科院分区：
文献类型：
--
作者：
Niu Y;Chen J;Qiao Y
肿瘤发生通常伴有慢性炎症，肿瘤微环境（tumor microenvironment， TME）可以被认为是一个由肿瘤细胞、内皮细胞、成纤维细胞、免疫细胞和细胞外基质等非细胞成分组成的生态系统。对于肿瘤细胞而言，其生存优势既依赖于遗传改变，也依赖于表观遗传改变，而其他细胞主要表现为表观遗传修饰。巨噬细胞是最具可塑性的免疫细胞类型，在TME中经历多种表观遗传改变。其中一些表观遗传修饰减缓了癌症的进展，而另一些则加速了这一进程。由于巨噬细胞在TME中的复杂作用，迫切需要了解它们与TME相关的表观遗传修饰。本文主要综述了肿瘤相关巨噬细胞（tme）表观遗传改变的最新研究成果，包括DNA甲基化、组蛋白翻译后修饰、染色质重塑和非编码rna介导的表观遗传调控。在这篇综述的最后，我们还讨论了这些表观遗传修饰在开发针对tam的新型癌症治疗中的转化潜力。
Tumorigenesis is frequently accompanied by chronic inflammation, and the tumor microenvironment (TME) can be considered an ecosystem that consists of tumor cells, endotheliocytes, fibroblasts, immune cells and acellular components such as extracellular matrix. For tumor cells, their survival advantages are dependent on both genetic and epigenetic alterations, while other cells mainly present epigenetic modifications. Macrophages are the most plastic type of immune cells and undergo diverse epigenetic alterations in the TME. Some of these epigenetic modifications mitigate against cancer progression, and others accelerate this process. Due to the complex roles of macrophages in the TME, it is urgent to understand their epigenetic modifications associated with the TME. Here, we mainly summarize recent findings on TME-associated epigenetic alterations of tumor-associated macrophages (TAMs), including DNA methylation, posttranslational modifications of histone proteins, chromatin remodeling, and noncoding RNA-mediated epigenetic regulation. At the end of this review, we also discuss the translational potential of these epigenetic modifications for developing novel cancer therapies targeting TAMs.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
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影响因子：
64.5
作者：
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Fitzgerald KA
影响因子：
82.9
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通讯作者：
Krummel MF
新型组蛋白翻译后修饰的蛋白质组学表征。
影响因子：
3.9
作者：
Arnaudo AM;Garcia BA
通讯作者：
Garcia BA