Abnormal reward system network in primary dysmenorrhea
Abnormal reward system network in primary dysmenorrhea
复制标题
原发性痛经的奖赏系统网络异常
DOI：
10.1177/1744806919862096
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发表时间：
2019-01
期刊：
影响因子：
3.3
通讯作者：
Jie Yang
中科院分区：
文献类型：
--
作者：
Qi Zhang;Siyi Yu;Yanan Wang;Minyu Wang;Ya Yang;Wei Wei;Xiaoli Guo;Fang Zeng;Fanrong Liang;Jie Yang
神经成像研究表明，奖赏系统与慢性疼痛疾病有关。此外，以前的研究也表明，原发性痛经的大脑功能和结构区域异常。然而，奖赏系统与原发性痛经的关系尚不清楚。应用静息状态功能磁共振成像技术，探讨原发性痛经患者排卵期奖赏系统功能连接的变化。41例原发性痛经患者和39例匹配的女性健康对照参与了这项研究。与健康对照组相比，原发性痛经患者左侧伏隔核与双侧前脑岛和左侧杏仁核的连接减弱，右侧伏隔核与腹侧被盖区、左侧海马体、右侧眶前皮质和右侧前岛的连接减弱。此外，右侧伏核-腹侧被盖区之间的功能连接性降低与前列腺素F2α水平呈负相关。我们的发现为支持原发性痛经患者奖赏系统连接异常提供了神经影像证据，这可能有助于更好地了解原发性痛经的大脑病理生理机制。
Neuroimaging studies have demonstrated that reward system is associated with chronic pain diseases. In addition, previous studies have also demonstrated abnormal functional and structural brain regions in primary dysmenorrhea. However, the relation of reward system and primary dysmenorrhea is still unknown. Using the resting state functional magnetic resonance imaging, we aimed to investigate the functional connectivity changes of reward system during periovulatory phase in primary dysmenorrhea. Forty-one primary dysmenorrhea patients and 39 matched female healthy controls participated in this study. Compared to healthy controls, primary dysmenorrhea patients showed decreased connectivity of left nucleus accumbens with the bilateral anterior insula and the left amygdala and decreased connectivity of right nucleus accumbens with ventral tegmental area, the left hippocampus, the right orbital frontal cortex, and the right anterior insula. In addition, the decreased functional connectivity between the right nucleus accumbens-ventral tegmental area negatively correlated with the level of prostaglandin F2 alpha. Our findings provide neuroimaging evidence in support of the abnormal reward system connectivity in primary dysmenorrhea patients, which might contribute to a better understanding of the cerebral pathophysiology of primary dysmenorrhea.
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影响因子：
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影响因子：
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