Mitochondrial DNA mutations and aging: devils in the details?
Mitochondrial DNA mutations and aging: devils in the details?
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线粒体DNA突变和衰老：细节中的魔鬼？
DOI：
10.1016/j.tig.2008.11.007
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发表时间：
2009-02
影响因子：
11.4
通讯作者：
Vijg, Jan
中科院分区：
文献类型：
--
作者：
Khrapko, Konstantin;Vijg, Jan
尽管有多条证据支持体细胞线粒体DNA（mtDNA）突变的积累在衰老病因学中起作用，但它们是否是年龄相关衰退和死亡的主要原因仍不清楚。携带较高mtDNA突变频率的小鼠模型会过早衰老；这些发现被认为为这类突变在衰老中的因果作用提供了确凿证据。然而，一些相互矛盾的报道引发了该领域的争议，并且mtDNA突变部分的估计差异进一步加剧了这种争议，这些估计差异可达数量级。在此，我们简要回顾了有关mtDNA突变积累在衰老中起致病作用的证据以及一些未解决的问题。
Although several lines of evidence support a role for accumulating somatic mitochondrial DNA (mtDNA) mutations in the etiology of aging, it remains unclear if they are a major cause of age-related deterioration and death. Mouse models that harbor elevated mtDNA mutation frequencies age prematurely; these findings were thought to provide conclusive evidence for a causal role of such mutations in aging. Yet, the presence of several conflicting reports has sparked controversy in the field and this is further aggravated by discrepancies in the estimates of mtDNA mutant fractions, which disagree by orders of magnitude. Here, we briefly review the evidence and some of the unresolved questions surrounding a causative role for accumulating mtDNA mutations in aging.
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影响因子：
14.9
作者：
CORTOPASSI, GA;ARNHEIM, N
通讯作者：
ARNHEIM, N
DOI：
10.1073/pnas.0505903103
发表时间：
2006-01-17
影响因子：
11.1
作者：
Greaves, LC;Preston, SL;McDonald, SAC
通讯作者：
McDonald, SAC
DOI：
10.1111/j.1532-5415.1972.tb00787.x
发表时间：
1972-01-01
影响因子：
6.3
作者：
HARMAN, D
通讯作者：
HARMAN, D
影响因子：
30.8
作者：
Cree, Lynsey M.;Samuels, David C.;Chinnery, Patrick F.
通讯作者：
Chinnery, Patrick F.
DOI：
10.1073/pnas.0308710100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Hansson, A;Hance, N;Larsson, NG
通讯作者：
Larsson, NG