Association between leisure sedentary behaviour and uterine fibroids in non-menopausal women: a population-based study.
Association between leisure sedentary behaviour and uterine fibroids in non-menopausal women: a population-based study.
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DOI：
10.1136/bmjopen-2023-073592
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发表时间：
2023-11-28
期刊：
影响因子：
2.9
通讯作者：
Meng, Qiong
中科院分区：
文献类型：
--
作者：
Sun, Yunrui;Han, Xiaoyu;Hou, Zhongxin;Deng, Haoyuan;Cheng, Nan;Zhang, Nishang;Zhang, Jianghui;Li, Yi;Wang, Qian;Yin, Jianzhong;Meng, Qiong
久坐行为与多种不良健康结果相关，包括肥胖、雌激素代谢和慢性炎症，所有这些都与子宫肌瘤（UF）的发病机制有关。本研究旨在探讨休闲静坐时间（LST）与 UF 之间的关系。横截面。我们对中国多民族队列研究中来自云南地区的患者数据进行了横断面分析。总共招募了 6623 名 30-55 岁的非绝经女性。自我报告月经状况。缺乏唯一国民身份证、患有严重精神疾病、没有明确诊断为 UF 或提供不完整信息的参与者被排除在外。 UF通过腹部B超诊断。通过面对面的问卷调查来评估休闲久坐行为。采用逻辑回归和限制三次样条来探讨 LST 和 UF 之间的关系。共有 562 名参与者患有 UF，患病率为 8.5%（7.8%、9.2%）。多变量调整logistic回归分析显示，LST≥6小时/天的女性发生UF的风险是LST<2小时/天的女性的2.008倍（95%CI 1.230至3.279）。受限三次样条结果表明，LST 和 UF 之间存在线性剂量反应关系（非线性 p>0.05）。根据月经状况和体重指数（BMI）的分层分析结果，仅在BMI<24kg/m2或围绝经期的女性中，LST与UF的患病率存在相关性。 LST 与 UF 的患病率独立相关，并且观察到线性剂量反应关系。我们的研究提供了影响UFs的因素的证据，需要进一步的研究来提出可行的UFs预防措施。
Sedentary behaviour is associated with a variety of adverse health outcomes, including obesity, oestrogen metabolism and chronic inflammation, all of which are related to the pathogenesis of uterine fibroids (UFs). This study aimed to explore the relationship between leisure sedentary time (LST) and UFs. Cross-sectional. We conducted a cross-sectional analysis of data from patients from the Yunnan region in the China Multi-Ethnic Cohort Study. A total of 6623 non-menopausal women aged 30–55 years old were recruited. Menstrual status was self-reported. Participants who lacked a unique national identity card, suffered from serious mental illness, did not have a clear diagnosis of UFs, or provided incomplete information were excluded. UFs were diagnosed by abdominal B-ultrasound. Leisure sedentary behaviour was assessed by using a face-to-face questionnaire interview. Logistic regression and restricted cubic spline were employed to explore the relationship between LST and UFs. A total of 562 participants had UFs, with a prevalence rate of 8.5% (7.8%, 9.2%). Multivariate adjusted logistic regression analysis showed that the risk of UFs in women with LST≥6 hour/day was 2.008 times that in women with LST<2 hour/day (95% CI 1.230 to 3.279). The restricted cubic spline results showed that there was a linear dose‒response relationship between LST and UFs (p for non-linearity>0.05). According to the results of the stratified analysis for menstrual status and body mass index (BMI), there was a correlation between LST and the prevalence of UFs only in women with a BMI<24 kg/m2 or perimenopause. LST was independently associated with the prevalence of UFs, and a linear dose‒response relationship was observed. Our study provides evidence on the factors influencing UFs, and further research is needed to propose feasible measures for UFs prevention.
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