Risk of uterine leiomyomata with menstrual and reproductive factors in premenopausal women: Korea nurses' health study.
Risk of uterine leiomyomata with menstrual and reproductive factors in premenopausal women: Korea nurses' health study.
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DOI：
10.1186/s12905-023-02447-4
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发表时间：
2023-06-09
影响因子：
2.5
通讯作者：
Park, Hyun-Young
中科院分区：
文献类型：
--
作者：
Song, Sihan;Park, Soojin;Song, Bo Mi;Lee, Jung Eun;Cha, Chiyoung;Park, Hyun-Young
子宫平滑肌瘤（UL）是良性平滑肌肿瘤，可能会导致显着的发病率在育龄妇女。本研究旨在探讨绝经前妇女的月经和生殖因素与UL风险的关系。这项前瞻性研究包括7，360名年龄在22-48岁之间的绝经前女性，她们是韩国护士健康研究的一部分。在2014年至2016年期间评估了有关月经周期和生殖史的信息，并在2021年之前获得了自我报告的UL病例。使用考克斯比例风险模型估计风险比（HR）和95%置信区间（CI）。在32，072人年的随访期间，报告了447例UL事件。校正其他风险因素后，初潮年龄较晚的女性UL发生率较低（≥ 16岁vs. 12-13岁：HR 0.68; 95% CI 0.47-0.99;趋势p = 0.026）。UL风险与当前月经周期长度（≥ 40或太不规则而无法估计vs. 26-31天：HR 0.40; 95% CI 0.24-0.66）和18-22岁时的周期长度（HR 0.45; 95% CI 0.31-0.67;趋势p < 0.001）呈负相关。经产妇女的UL风险低于未经产妇女（HR 0.40; 95% CI 0.30-0.53），初次生育时年龄为29-30岁的妇女的UL风险低于初次生育时年龄≤ 28岁的妇女（HR 0.58; 95% CI 0.34-0.98）。分娩次数或母乳喂养与经产妇女UL风险无显著相关性。不孕症史和口服避孕药使用与UL风险无关。我们的研究结果表明，初潮年龄，月经周期长度，产次，和年龄在第一次生育的风险呈负相关的绝经前韩国妇女UL。未来的研究有必要确认月经和生殖因素对妇女健康的长期影响。
Uterine leiomyomata (UL) are benign smooth muscle tumors that may cause significant morbidity in women of reproductive age. This study aimed to investigate the relationship of menstrual and reproductive factors with the risk of UL in premenopausal women. This prospective study included 7,360 premenopausal women aged 22–48 years who were part of the Korea Nurses’ Health Study. Information on the menstrual cycle and reproductive history was assessed between 2014 and 2016, and self-reported cases of UL were obtained through 2021. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). During 32,072 person-years of follow-up, 447 incident cases of UL were reported. After adjusting for other risk factors, women with late age at menarche had a lower incidence of UL (≥ 16 vs. 12–13 years: HR 0.68; 95% CI 0.47–0.99; p for trend = 0.026). The risk of UL was inversely associated with current menstrual cycle length (≥ 40 or too irregular to estimate vs. 26–31 days: HR 0.40; 95% CI 0.24–0.66) and cycle length at ages 18–22 years (HR 0.45; 95% CI 0.31–0.67; p for trend < 0.001, each). Parous women had lower risk of UL than nulliparous women (HR 0.40; 95% CI 0.30–0.53) and women who were aged 29–30 years at first birth had a lower risk of UL than those who were aged ≤ 28 years at first birth (HR 0.58; 95% CI 0.34–0.98). There was no significant association of the number of births or breastfeeding with the risk of UL among parous women. Neither a history of infertility nor oral contraceptive use was associated with the risk of UL. Our results suggest that age at menarche, menstrual cycle length, parity, and age at first birth are inversely associated with the risk of UL in premenopausal Korean women. Future studies are warranted to confirm the long-term effects of menstrual and reproductive factors on women’s health.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1007/bf01606522
发表时间：
1991-01-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
KAWAGUCHI, K;FUJII, S;MORI, T
通讯作者：
MORI, T
影响因子：
5.8
作者：
MUSEY, VC;COLLINS, DC;PREEDY, JRK
通讯作者：
PREEDY, JRK
影响因子：
5.4
作者：
Parazzini, F;Negri, E;Guarnerio, P
通讯作者：
Guarnerio, P
影响因子：
2.7
作者：
Laughlin SK;Schroeder JC;Baird DD
通讯作者：
Baird DD