Parametric subharmonic imaging using a commercial intravascular ultrasound scanner: an in vivo feasibility study.
Parametric subharmonic imaging using a commercial intravascular ultrasound scanner: an in vivo feasibility study.
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DOI：
10.7863/jum.2012.31.3.361
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Forsberg F
中科院分区：
文献类型：
--
作者：
Eisenbrey JR;Sridharan A;deMuinck ED;Doyley MM;Forsberg F
在体内研究了利用参数化亚谐波血管内超声（IVUS）可视化动脉粥样硬化斑块的可行性。在2只家兔的主动脉中诱导动脉粥样硬化。注射去甲肾上腺素（Lantheus Medical Imaging，North Billerica，MA）后，使用Galaxy IVUS扫描仪（Boston Scientific/Scimed，Natick，MA）在40 MHz下采集射频IVUS信号。通过应用8阶均衡滤波器离线进行次谐波成像（SHI;接收频率为20 MHz）。计算4个时间点内血管相对于斑块面积的对比度-组织比（CTR）。还计算了4个时间点4个感兴趣组织区域的斑块-组织和血管-组织的对比度-组织比。最后，参数图像显示的累积最大强度（CMI），达到峰值的时间，灌注（PER），和时间积分强度（TII）的基波和次谐波数据集，并重复CTR测量。注射造影剂改善了斑块和血管腔之间的轮廓。次谐波成像导致明显的组织抑制，尽管造影剂的强度降低。在次谐波和基波IVUS之间未观察到斑块-血管腔CTR的显著改善（2.1 ± 3.64 vs 2.2 ± 4.20; P = 0.5）。然而，相对于基波成像，SHI的斑块组织CTR有所改善（11.8 ± 7.32 vs 9.9 ± 7.06; P <0.0001）。基波和次谐波数据的累积最大强度和TII图提供了相对于非参数数据集的增加的CTR（P< .002）。此外，SHI IVUS的CMI、PER和TII显示SHI相对于基础的血管斑块CTR显著改善（P <0.04）。动脉粥样硬化斑块的参数SHI IVUS是可行的，并提高了斑块的可视化。
The feasibility of visualizing atherosclerotic plaque using parametric subharmonic intravascular ultrasound (IVUS) was investigated in vivo. Atherosclerosis was induced in the aorta of 2 rabbits. Following injection of Definity (Lantheus Medical Imaging, North Billerica, MA), radiofrequency IVUS signals were acquired at 40 MHz with a Galaxy IVUS scanner (Boston Scientific/Scimed, Natick, MA). Subharmonic imaging (SHI; receiving at 20 MHz) was performed offline by applying an 8-order equalization filter. Contrast-to-tissue ratios (CTRs) were computed for the vessel relative to the plaque area over 4 time points. Contrast-to-tissue ratios were also calculated for the plaque-tissue and vessel-tissue from 4 tissue regions of interest at 4 time points. Finally, parametric images showing the cumulative maximum intensity (CMI), time to peak, perfusion (PER), and time-integrated intensity (TII) were generated for the fundamental and subharmonic data sets, and CTR measurements were repeated. Injection of the contrast agent resulted in improved delineation between plaque and the vessel lumen. Subharmonic imaging resulted in noticeable tissue suppression, although the intensity from the contrast agent was reduced. No significant improvement in the plaque to vessel lumen CTR was observed between the subharmonic and fundamental IVUS (2.1 ± 3.64 versus 2.2 ± 4.20; P = .5). However, the CTR for plaque-tissue was improved (11.8 ± 7.32 versus 9.9 ± 7.06; P < .0001) for SHI relative to fundamental imaging. Cumulative-maximum-intensity and TII maps of both fundamental and subharmonic data provided increased CTRs relative to nonparametric data sets (P< .002). Additionally, the CMI, PER, and TII of SHI IVUS showed significantly improved vessel-plaque CTRs for SHI relative to the fundamental (P < .04). Parametric SHI IVUS of atherosclerotic plaque is feasible and improves the visualization of the plaque.
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影响因子：
6.7
作者：
Goertz, David E.;Frijlink, Martijn E.;van der Steen, Antonius F. W.
通讯作者：
van der Steen, Antonius F. W.
DOI：
10.1109/tuffc.2005.1397351
发表时间：
2005-01-01
影响因子：
3.6
作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
Brindle, NPJ
影响因子：
4.2
作者：
Forsberg, F;Shi, WT;Goldberg, BB
通讯作者：
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影响因子：
2.3
作者：
Forsberg, F;Liu, JB;Hall, AL
通讯作者：
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