Chemical composition, antifungal and antitumor properties of ether extracts of Scapania verrucosa Heeg. and its endophytic fungus Chaetomium fusiforme.
Chemical composition, antifungal and antitumor properties of ether extracts of Scapania verrucosa Heeg. and its endophytic fungus Chaetomium fusiforme.
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DOI：
10.3390/molecules13092114
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发表时间：
2008-09-04
期刊：
影响因子：
--
通讯作者：
Qin LP
中科院分区：
文献类型：
--
作者：
Guo L;Wu JZ;Han T;Cao T;Rahman K;Qin LP
羊栖菜内生真菌Chaetomium fusiforme从苔类植物Scapania verrucosa中分离得到。比较了S. verrucosa和C.采用气相色谱-质谱联用技术（GC/MS）对羊栖菜发酵液进行了研究。乙醚提取物的得率为0.6%，共鉴定出59个化合物。疣状的在49种化合物中，含量最高的是（+）-芳香树烯（9.12%）、十六烷酸（6.92%）、6-异丙烯基-4，8a-二甲基-1，2，3，5，6，7，8，8a-八氢萘-2-醇（5.97%）、s-四氯乙烷（5.61%）和乙酸（5.30%）。疣果占总提取物的84.64%。而内生真菌培养液中主要含有乙酸（35.05%）、戊酸甲酯（21.25%）和丁二醇（12.24%）。虽然S. verrucosa及其内生菌的化学成分相关性不大，但均具有抗真菌和抗肿瘤活性。此外，C.羊栖菜具有较强的抑菌和抗肿瘤活性，其抑菌和抗肿瘤活性均优于寄主植物。这些结果可能支持内生菌作为宿主的替代药物活性的建议。
An endophytic fungus Chaetomium fusiforme was obtained from a liverwort, Scapania verrucosa. A comparison of the constituents of the ether extracts between S. verrucosa and the C. fusiforme culture was investigated by gas chromatography-mass spectrometry (GC/MS). The yield of ether extract based on dried plant material was 0.6% and 59 compounds were found in S. verrucosa. (+)-Aromadendrene (9.12%), hexadecanoic acid (6.92%), 6-isopropenyl-4,8a-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-2-ol (5.97%), s-tetrachloroethane (5.61%) and acetic acid (5.30%) were found to be the most abundant components among the 49 characterized compounds in S. verrucosa, which represented 84.64% of the total extract. However, the constituents of the cultured endophyte extract contained mainly acetic acid (35.05%), valeric acid, 3-methyl-, methyl ester (21.25%), and butane-2, 3-diol (12.24%). Although the extracts of S. verrucosa and its endophyte showed little chemical composition correlation, both of them demonstrated antifungal and antitumor activities. Furthermore, C. fusiforme has displayed a wider range of antimicrobial and antitumor activities, which were better than the host plant. These results could support the suggestion of endophytes as an alternative of the host for medicinal activity.
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影响因子：
4.8
作者：
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