An artificial intelligence-assisted diagnostic platform for rapid near-patient hematology.

An artificial intelligence-assisted diagnostic platform for rapid near-patient hematology.
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DOI:
10.1002/ajh.26295
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发表时间:
2021-10-01
影响因子:
12.8
通讯作者:
Brugnara, Carlo
Brugnara, Carlo
中科院分区:
医学1区
文献类型:
--
作者:
Bachar, Neta;Benbassat, Dana;Brailovsky, David;Eshel, Yochay;Gluck, Dan;Levner, Daniel;Levy, Sarah;Pecker, Sharon;Yurkovsky, Evgeny;Zait, Amir;Sever, Cordelia;Kratz, Alexander;Brugnara, Carlo

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能够进行全血细胞计数(CBC)的血液学分析仪在护理点的流行程度落后。Sight OLO (Sight Diagnostics, Israel)是一种新型血液学平台,它提供19个参数,五部分差分CBC,旨在解决当前使用人工智能(AI)和计算机视觉的最新进展的护理点血液学分析仪的局限性。将OLO的准确性、可重复性和标记能力与Sysmex XN系列系统(Sysmex,日本)进行比较。基质研究比较了静脉、毛细血管和直接从手指穿刺血液样本的性能。回归分析表明,OLO与Sysmex XN具有较强的一致性,表明OLO对所有CBC参数都具有较高的准确性。结果表明,大多数测试参数具有较高的重复性和再现性。OLO血液学分析仪的分析性能在多中心临床实验室环境中得到验证,证明了其准确性和与临床实验室血液学分析仪的可比性。此外,该研究还证明了直接从指纹中采集样本的CBC分析的有效性。
Hematology analyzers capable of performing complete blood count (CBC) have lagged in their prevalence at the point‐of‐care. Sight OLO (Sight Diagnostics, Israel) is a novel hematological platform which provides a 19‐parameter, five‐part differential CBC, and is designed to address the limitations in current point‐of‐care hematology analyzers using recent advances in artificial intelligence (AI) and computer vision. Accuracy, repeatability, and flagging capabilities of OLO were compared with the Sysmex XN‐Series System (Sysmex, Japan). Matrix studies compared performance using venous, capillary and direct‐from‐fingerprick blood samples. Regression analysis shows strong concordance between OLO and the Sysmex XN, demonstrating that OLO performs with high accuracy for all CBC parameters. High repeatability and reproducibility were demonstrated for most of the testing parameters. The analytical performance of the OLO hematology analyzer was validated in a multicenter clinical laboratory setting, demonstrating its accuracy and comparability to clinical laboratory‐based hematology analyzers. Furthermore, the study demonstrated the validity of CBC analysis of samples collected directly from fingerpricks.
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