The mutacins of Streptococcus mutans: regulation and ecology.
The mutacins of Streptococcus mutans: regulation and ecology.
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DOI：
10.1111/j.2041-1014.2011.00634.x
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发表时间：
2012-04
影响因子：
3.7
通讯作者：
Qi F
中科院分区：
文献类型：
--
作者：
Merritt J;Qi F
变形链球菌是公认的人类龋病的病原体。变形链球菌产生的变形链菌素(细菌素)被认为是变形链球菌在牙科生物膜中定植和建立的重要因素。变形菌素有两种类型：一种是抗生素，另一种是非抗生素。抗生素通常比非抗生素具有更广泛的活性范围，这使它们成为开发新的抗菌药物的有吸引力的目标。非抗生素在变形链球菌中更为普遍，并在牙科生物膜的群落和种群水平的相互作用中发挥着重要作用。这些相互作用是通过ComCDE双组分系统和新鉴定的LytTR调节系统HdrRM和BrsRM直接调节的。这些系统协调自然能力的发展和突变素的产生，作为一种获得转化DNA的手段，要么通过杀死变形链球菌附近密切相关的链球菌物种，要么通过在变形链球菌群落内的一群合格细胞中进行无私的自杀机制。随着更多的变形链球菌被测序，预计将发现更多具有新功能的突变素，这可能会进一步深入了解突变素在口腔生物膜中的生态作用。
Streptococcus mutans is generally recognized as a causative agent of human dental caries. The production of mutacins (bacteriocins) by S. mutans is considered to be an important factor in the colonization and establishment of S. mutans in the dental biofilm. Two types of mutacins have been characterized: the lantibiotics and the non-lantibiotics. The lantibiotics generally have a wider spectrum of activity than the non-lantibiotics, which make them attractive targets for development into new antimicrobial modalities. The non-lantibiotics are much more prevalent among strains of S. mutans and play a significant role in both community and population level interactions in the dental biofilm. These interactions are directly mediated through the ComCDE two-component system and the newly characterized LytTR Regulation Systems HdrRM and BrsRM. These systems coordinate natural competence development and mutacin production as a means to acquire transforming DNA either by killing closely related streptococcal species in the vicinity of S. mutans, or through an altruistic suicide mechanism among a subpopulation of competent cells within the S. mutans community. As more S. mutans strains are sequenced, it is anticipated that additional mutacins with novel functions will be discovered, which may yield further insights into the ecological role of mutacins within the oral biofilm.
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影响因子：
3.2
作者：
Dufour, Delphine;Cordova, Martha;Levesque, Celine M.
通讯作者：
Levesque, Celine M.
影响因子：
4.8
作者：
Chan, C;Burrows, LL;Deber, CM
通讯作者：
Deber, CM
影响因子：
4.9
作者：
DELISLE, AL
通讯作者：
DELISLE, AL
影响因子：
4.4
作者：
Hale, JDF;Ting, YT;Heng, NCK
通讯作者：
Heng, NCK
影响因子：
2.1
作者：
Aspiras, MB;Ellen, RP;Cvitkovitch, DG
通讯作者：
Cvitkovitch, DG