Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons.
Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons.
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DOI：
10.1111/ejn.13287
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Blackwell KT
中科院分区：
文献类型：
--
作者：
Jędrzejewska-Szmek J;Damodaran S;Dorman DB;Blackwell KT
The striatum is a major site of learning and memory formation for sensorimotor and cognitive association. One of the mechanisms used by the brain for memory storage is synaptic plasticity – the long lasting, activity-dependent change in synaptic strength. All forms of synaptic plasticity require an elevation in intracellular calcium, and a common hypothesis is that the amplitude and duration of calcium transients can determine the direction of synaptic plasticity. The utility of this hypothesis in the striatum is unclear in part because dopamine is required for striatal plasticity and in part because of the diversity in stimulation protocols. To test whether calcium can predict plasticity direction, we developed a calcium-based plasticity rule using a spiny projection neuron model with sophisticated calcium dynamics including calcium diffusion, buffering, and pump extrusion. We utilize three spike-timing-dependent plasticity (STDP) induction protocols, in which post-synaptic potentials are paired with precisely timed action potentials and the timing of such pairing determines whether potentiation or depression will occur. Results show that despite the variation in calcium dynamics, a single, calcium-based plasticity rule, which explicitly considers duration of calcium elevations, can explain the direction of synaptic weight change for all three STDP protocols. Additional simulations show that the plasticity rule correctly predicts the NMDA receptor dependence of long-term potentiation and the L-type channel dependence of long term depression. By utilizing realistic calcium dynamics, the model reveals mechanisms controlling synaptic plasticity direction, and shows that the dynamics of calcium, not just calcium amplitude, are crucial for synaptic plasticity. We created a model spiny projection neuron with dendrites, spines and realistic calcium dynamics to investigate synaptic plasticity. Synaptic strength increases when calcium exceeds an upper threshold for a specified duration, and decreases when calcium is between the upper and lower threshold for a specified duration. This learning rule accurately predicts the timing- and NMDA-dependence of STDP, and further predicts that L type calcium channels are required for LTD.
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影响因子：
2.5
作者：
Foehring, RC;Mermelstein, PG;Surmeier, DJ
通讯作者：
Surmeier, DJ
影响因子：
5.5
作者：
Fino, Elodie;Paille, Vincent;Venance, Laurent
通讯作者：
Venance, Laurent
影响因子：
2.5
作者：
Brevi, S;de Curtis, M;Magistretti, J
通讯作者：
Magistretti, J
影响因子：
2.5
作者：
Kerr, JND;Wickens, JR
通讯作者：
Wickens, JR
DOI：
10.1523/jneurosci.2628-11.2011
发表时间：
2011-11-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ibáñez-Sandoval O;Tecuapetla F;Unal B;Shah F;Koós T;Tepper JM
通讯作者：
Tepper JM