Immunomodulatory effect of dimethyloxallyl glycine/nanosilicates-loaded fibrous structure on periodontal bone remodeling.
Immunomodulatory effect of dimethyloxallyl glycine/nanosilicates-loaded fibrous structure on periodontal bone remodeling.
复制标题
二甲基乙二酰甘氨酸/纳米硅酸盐负载纤维结构对牙周骨重塑的免疫调节作用
DOI：
10.1016/j.jds.2020.10.008
复制
发表时间：
2021-07
影响因子：
3.5
通讯作者：
Ge SH
中科院分区：
文献类型：
--
作者：
Liu ZQ;Shang LL;Ge SH
减轻免疫炎症反应是治疗牙周炎的先决条件。血管生成小分子DMOG和骨诱导无机纳米材料nSi对骨再生有很强的作用，但在骨免疫调节中的作用尚未完全揭示。本研究旨在探讨DMOG/nSi负载纤维膜对牙周骨改建的免疫调节作用。采用静电纺丝法将DMOG和nSi引入到聚乳酸-羟基乙酸共聚物（PLGA）中制备纤维膜。对DMOG/nSi-PLGA纤维膜的形态特征、表面化学性质及生物相容性进行了表征。然后将纤维膜植入大鼠牙周缺损区，通过显微CT、组织学和免疫组化观察纤维膜的骨重建能力和免疫调节作用。DMOG/nSi-PLGA膜具有良好的理化性能和生物相容性。DMOG/nSi-PLGA复合膜植入牙周缺损区后，可减轻缺损区的免疫炎症反应（炎性细胞浸润减少，CD 40 L和CD 11b阳性细胞减少），增加CD 206阳性M2巨噬细胞，促进牙周骨再生。DMOG/nSi-PLGA纤维膜在牙周骨缺损修复过程中发挥保护作用，并引导免疫反应向骨再生方向发展。因此，DMOG/nSi-PLGA纤维膜有望成为牙周组织工程的理想支架材料。
Relieving immuno-inflammatory responses is the prerequisite step for treating periodontitis. The angiogenic small molecule, dimethyloxalylglycine (DMOG), and osteoinductive inorganic nanomaterial, nanosilicate (nSi) have a powerful effect on bone regeneration, whereas the roles in osteoimmunomodulation have not been totally uncovered. Our study aimed to explore the immunomodulatory effect of DMOG/nSi-loaded fibrous membranes on periodontal bone remodeling. The fibrous membranes were prepared by incorporating DMOG and nSi into poly (lactic-co-glycolic acid) (PLGA) with electrospinning. The morphology features, surface chemical property and biocompatibility of DMOG/nSi-PLGA fibrous membranes were characterized. Thereafter, the fibrous membranes were implanted into rat periodontal defects, bone remodeling potential and immunomodulatory effect were evaluated by micro-computed tomography (micro-CT), histological evaluation and immunohistochemical analysis. DMOG/nSi-PLGA membranes possessed favorable physicochemical properties and biocompatibility. After the fibrous membranes implanted into periodontal defects, DMOG/nSi-PLGA membranes could relieve immuno-inflammatory responses of the defects (reduction of inflammatory cell infiltration, CD40L and CD11b-positive cells), increased CD206-positive M2 macrophages, and eventually facilitated periodontal bone regeneration. DMOG/nSi-PLGA fibrous membranes exert protective effects during periodontal bone defect repairing, and steer immune response towards bone regeneration. Consequently, DMOG/nSi-PLGA fibrous membranes may serve as a promising scaffold in periodontal tissue engineering.
登录
查看更多内容
羟化酶抑制剂二甲氧亚甘氨酸通过巨噬细胞的替代激活和B1细胞产生的IL-10产生来减轻内毒性休克。
DOI：
10.1097/shk.0b013e318225ad7e
发表时间：
2011-09
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Hams E;Saunders SP;Cummins EP;O'Connor A;Tambuwala MT;Gallagher WM;Byrne A;Campos-Torres A;Moynagh PM;Jobin C;Taylor CT;Fallon PG
通讯作者：
Fallon PG
影响因子：
4.6
作者：
Alvarez C;Rojas C;Rojas L;Cafferata EA;Monasterio G;Vernal R
通讯作者：
Vernal R
影响因子：
29.4
作者：
Cummins, Eoin P.;Seeballuck, Fergal;Taylor, Cormac T.
通讯作者：
Taylor, Cormac T.
影响因子：
29.4
作者：
Gaharwar, Akhilesh K.;Mihaila, Silvia M.;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
DOI：
10.18632/aging.101651
发表时间：
2018-11-16
期刊：
Aging
影响因子：
--
作者：
Han L;Dai L;Zhao YF;Li HY;Liu O;Lan F;Jiang WJ;Zhang HJ
通讯作者：
Zhang HJ