Role of the Preoptic Area in Sleep and Thermoregulation.
Role of the Preoptic Area in Sleep and Thermoregulation.
复制标题
DOI：
10.3389/fnins.2021.664781
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Chung S
中科院分区：
文献类型：
--
作者：
Rothhaas R;Chung S
在哺乳动物中，睡眠和体温是紧密相连的：温暖我们的身体有助于入睡，而入睡时体温反过来会下降。下丘脑视前区（POA）是协调睡眠和体温的重要脑区。了解这两种行为是如何在POA内控制的，需要对所涉及的回路进行分子识别，并绘制它们的局部和全脑连接。在这里，我们回顾了我们目前对睡眠和体温是如何调节的理解，重点是最近发现的睡眠和体温调节POA神经元。我们进一步讨论了尚未解决的关键问题，包括睡眠和体温调节神经元的解剖和功能重叠，它们的通路和各种信号分子的作用。我们认为，对遗传定义的回路的分析将为健康和疾病中睡眠和体温协调调节的机制提供新的见解。
Sleep and body temperature are tightly interconnected in mammals: warming up our body helps to fall asleep and the body temperature in turn drops while falling asleep. The preoptic area of the hypothalamus (POA) serves as an essential brain region to coordinate sleep and body temperature. Understanding how these two behaviors are controlled within the POA requires the molecular identification of the involved circuits and mapping their local and brain-wide connectivity. Here, we review our current understanding of how sleep and body temperature are regulated with a focus on recently discovered sleep- and thermo-regulatory POA neurons. We further discuss unresolved key questions including the anatomical and functional overlap of sleep- and thermo-regulatory neurons, their pathways and the role of various signaling molecules. We suggest that analysis of genetically defined circuits will provide novel insights into the mechanisms underlying the coordinated regulation of sleep and body temperature in health and disease.
登录
查看更多内容
影响因子：
5.5
作者：
BOULANT, JA;HARDY, JD
通讯作者：
HARDY, JD
影响因子：
2.9
作者：
CARLISLE, HJ;LAUDENSLAGER, ML
通讯作者：
LAUDENSLAGER, ML
DOI：
10.1152/ajpregu.00093.2005
发表时间：
2005-09-01
影响因子：
2.8
作者：
Baker, FC;Angara, C;McGinty, D
通讯作者：
McGinty, D
影响因子：
5.6
作者：
BUNNELL, DE;AGNEW, JA;WILLS, M
通讯作者：
WILLS, M
影响因子：
2.8
作者：
CAMPBELL, SS;BROUGHTON, RJ
通讯作者：
BROUGHTON, RJ