Saitohin Q7R polymorphism is associated with late-onset Alzheimer's disease susceptibility among caucasian populations: a meta-analysis.
Saitohin Q7R polymorphism is associated with late-onset Alzheimer's disease susceptibility among caucasian populations: a meta-analysis.
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DOI：
10.1111/jcmm.13079
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发表时间：
2017-08
影响因子：
5.3
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Huang R;Tian S;Cai R;Sun J;Xia W;Dong X;Shen Y;Wang S
据报道，Saitohin (STH) Q7R多态性影响个体对阿尔茨海默病（AD）的易感性；然而，结论仍然存在争议。因此，我们进行了这项荟萃分析，以探索STH Q7R多态性与AD风险之间的关系。在PubMed、Embase、Cochrane Library和Web of Science中进行系统文献检索，检索2016年8月31日前发表的研究。使用固定效应或随机效应模型计算合并优势比（ORs）和95%置信区间（ci），以评估相关性的强度。并进行亚组分析、Galbraith图和敏感性分析。所有统计分析均使用STATA Version 12.0进行。我们的meta分析共纳入了来自17篇出版物的19项病例对照研究，涉及4387例病例和3972例对照。结果显示，在隐性模型中，Q7R多态性与AD风险增加显著相关（RR vs QQ+QR, OR = 1.27, 95% CI = 1.01 ~ 1.60, P = 0.040）。在排除了未在白种人中进行的四项研究后，所有比较模型的总体关联没有变化。进一步的亚组分析按阿尔茨海默病发病时间分层，纳入的研究质量提供了统计学证据，表明只有晚发病受试者（OR = 1.56, 95% CI = 1.07-2.26, P = 0.021）和高质量研究（OR = 1.37, 95% CI = 1.01-1.86, P = 0.043）与QQ+QR模型相比，RR模型中阿尔茨海默病的风险显著增加。这项荟萃分析表明，saitoin Q7R多态性中的RR基因型可能是阿尔茨海默病的人类特异性危险因素，特别是在晚发性阿尔茨海默病受试者和高加索人群中。
Saitohin (STH) Q7R polymorphism has been reported to influence the individual's susceptibility to Alzheimer's disease (AD); however, conclusions remain controversial. Therefore, we performed this meta‐analysis to explore the association between STH Q7R polymorphism and AD risk. Systematic literature searches were performed in the PubMed, Embase, Cochrane Library and Web of Science for studies published before 31 August 2016. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association using a fixed‐ or random‐effects model. Subgroup analyses, Galbraith plot and sensitivity analyses were also performed. All statistical analyses were performed with STATA Version 12.0. A total of 19 case–control studies from 17 publications with 4387 cases and 3972 controls were included in our meta‐analysis. The results showed that the Q7R polymorphism was significantly associated with an increased risk of AD in a recessive model (RR versus QQ+QR, OR = 1.27, 95% CI = 1.01–1.60, P = 0.040). After excluding the four studies not carried out in caucasians, the overall association was unchanged in all comparison models. Further subgroup analyses stratified by the time of AD onset, and the quality of included studies provided statistical evidence of significant increased risk of AD in RR versus QQ+QR model only in late‐onset subjects (OR = 1.56, 95% CI = 1.07–2.26, P = 0.021) and in studies with high quality (OR = 1.37, 95% CI = 1.01–1.86, P = 0.043). This meta‐analysis suggests that the RR genotype in saitohin Q7R polymorphism may be a human‐specific risk factor for AD, especially among late‐onset AD subjects and caucasian populations.
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影响因子：
15.8
作者：
Pan Z;Trikalinos TA;Kavvoura FK;Lau J;Ioannidis JP
通讯作者：
Ioannidis JP
DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
4.7
作者：
Conrad, C;Vianna, C;Davies, P
通讯作者：
Davies, P
影响因子：
2.5
作者：
Clark, LN;Levy, G;Marder, K
通讯作者：
Marder, K
影响因子：
2.4
作者：
Mateo, I;Infante, J;Combarros, O
通讯作者：
Combarros, O