Potential risk of mitomycin C at high concentrations on peripheral nerve structure.
Potential risk of mitomycin C at high concentrations on peripheral nerve structure.
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高浓度丝裂霉素 C 对周围神经结构的潜在风险
DOI：
10.4103/1673-5374.131598
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发表时间：
2014-04-15
影响因子：
6.1
通讯作者：
Cao X
中科院分区：
文献类型：
--
作者：
Sui T;Zhang J;Du S;Su C;Que J;Cao X
虽然局部应用丝裂霉素C可以防止椎板切除术后硬膜外粘连，但高浓度丝裂霉素C可引起视神经和听神经的神经毒性。为确定丝裂霉素C的安全浓度范围，将丝裂霉素C以不同浓度（0.1、0.3、0.5、0.7 mg/mL）浸泡在L1处行椎板切除术的大鼠的手术区域，立即将棉垫敷5分钟。本研究采用大鼠坐骨神经代替背神经。结果表明，0.1 ~ 0.5 mg/mL丝裂霉素C对坐骨神经的结构和功能没有损害，而0.7 mg/mL丝裂霉素C与较低浓度相比，显著降低了坐骨神经髓鞘的厚度，但未见功能改变。这些实验结果表明，局部应用低浓度丝裂霉素C对预防椎板切除术后瘢痕粘连是安全的，但高浓度丝裂霉素C （> 0.7 mg/mL）对周围神经结构有潜在的安全风险。
Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations (0.1, 0.3, 0.5, and 0.7 mg/mL) were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1-0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C significantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concentrations, though no functional change was found. These experimental findings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations (> 0.7 mg/mL) has potential safety risks to peripheral nerve structures.
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影响因子：
3.4
作者：
Laughlin, Ruple S.;Spinner, Robert J.;Daube, Jasper R.
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/0360-3016(91)90265-6
发表时间：
1991-10-01
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影响因子：
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作者：
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