A simulation model of the within-host dynamics of Plasmodium vivax infection.
A simulation model of the within-host dynamics of Plasmodium vivax infection.
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DOI：
10.1186/s12936-015-0580-z
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发表时间：
2015-02-05
期刊：
影响因子：
3
通讯作者：
Gatton ML
中科院分区：
文献类型：
--
作者：
Kerlin DH;Gatton ML
间日疟原虫的良好声誉与该疾病的负担和严重程度不一致。这种声誉，加上有限的体外技术，减缓了对寄生虫生物学及其与人类宿主相互作用的理解。描述了间日疟原虫感染的宿主内动态的模拟模型，该模型结合了寄生虫的独特特征，例如网织红细胞的优先入侵和催眠子的产生。所开发的模型使用来自历史神经梅毒研究的数字化时间序列进行拟合，随后对来自同一人群的更大研究的汇总统计进行验证。Chesson复发模式用于证明释放的催眠虫的影响。寄生虫种群动态的典型模式是在前10天内迅速指数增长，随后逐渐下降。配子细胞计数遵循类似的趋势，但大约低两个数量级。该模型预测，平均而言，未接受治疗的受感染初始宿主在通畅后7.9天变得具有传染性，平均具有传染性的时间为34.4天。在未治疗的情况下，催眠虫释放的效果不明显，因为新释放的寄生虫被现有感染所掩盖。该模型的结果为间日疟原虫感染人类宿主的动力学提供了有用的见解，特别是宿主感染性的时间和催眠虫在持续感染中的作用。
The benign reputation of Plasmodium vivax is at odds with the burden and severity of the disease. This reputation, combined with restricted in vitro techniques, has slowed efforts to gain an understanding of the parasite biology and interaction with its human host. A simulation model of the within-host dynamics of P. vivax infection is described, incorporating distinctive characteristics of the parasite such as the preferential invasion of reticulocytes and hypnozoite production. The developed model is fitted using digitized time-series’ from historic neurosyphilis studies, and subsequently validated against summary statistics from a larger study of the same population. The Chesson relapse pattern was used to demonstrate the impact of released hypnozoites. The typical pattern for dynamics of the parasite population is a rapid exponential increase in the first 10 days, followed by a gradual decline. Gametocyte counts follow a similar trend, but are approximately two orders of magnitude lower. The model predicts that, on average, an infected naïve host in the absence of treatment becomes infectious 7.9 days post patency and is infectious for a mean of 34.4 days. In the absence of treatment, the effect of hypnozoite release was not apparent as newly released parasites were obscured by the existing infection. The results from the model provides useful insights into the dynamics of P. vivax infection in human hosts, in particular the timing of host infectiousness and the role of the hypnozoite in perpetuating infection.
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高温温度可以在体外同步恶性疟原虫的生长。
DOI：
10.1084/jem.169.1.357
发表时间：
1989-01-01
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
1997-05-01
影响因子：
2.2
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通讯作者：
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影响因子：
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作者：
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作者：
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