Thymic development of gut-microbiota-specific T cells.
Thymic development of gut-microbiota-specific T cells.
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DOI：
10.1038/s41586-021-03531-1
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发表时间：
2021-06
期刊：
影响因子：
64.8
通讯作者：
Diehl GE
中科院分区：
文献类型：
--
作者：
Zegarra-Ruiz DF;Kim DV;Norwood K;Kim M;Wu WH;Saldana-Morales FB;Hill AA;Majumdar S;Orozco S;Bell R;Round JL;Longman RS;Egawa T;Bettini ML;Diehl GE
人类和他们的微生物群共同进化出一种互惠互利的关系，其中人类宿主为微生物提供了一个友好的环境，微生物群为宿主提供了许多优势，包括营养价值和对病原体感染的保护。维持这种关系需要仔细的免疫平衡，以遏制管腔内的共生微生物，同时限制炎性反共生反应。T细胞对肠道微生物的抗原特异性识别以前已经被描述过。尽管局部环境决定了效应细胞的分化，但微生物区系特异性T细胞是如何在胸腺中培养的还不清楚。在这里，我们表明在生命早期的肠道定植导致微生物抗原通过肠道树突状细胞从肠道运输到胸腺，然后诱导微生物区系特异性T细胞的扩张。一旦进入外围，微生物区系特异性T细胞就具有致病潜力或可以保护自己免受相关病原体的侵袭。通过这种方式，发育中的微生物群形成并扩大了胸腺和外周T细胞库，从而增强了对肠道微生物和病原体的识别。
Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection. Maintaining this relationship requires a careful immune balance to contain commensal microorganisms within the lumen while limiting inflammatory anti-commensal responses. Antigen-specific recognition of intestinal microorganisms by T cells has previously been described. Although the local environment shapes the differentiation of effector cells it is unclear how microbiota-specific T cells are educated in the thymus. Here we show that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells. Once in the periphery, microbiota-specific T cells have pathogenic potential or can protect against related pathogens. In this way, the developing microbiota shapes and expands the thymic and peripheral T cell repertoire, allowing for enhanced recognition of intestinal microorganisms and pathogens.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
48
作者：
Engstrom, Par G.;Steijger, Tamara;Sipos, Botond;Grant, Gregory R.;Kahles, Andre;Raetsch, Gunnar;Goldman, Nick;Hubbard, Tim J.;Harrow, Jennifer;Guigo, Roderic;Bertone, Paul
通讯作者：
Bertone, Paul
影响因子：
5.3
作者：
Jung, S;Aliberti, J;Littman, DR
通讯作者：
Littman, DR
影响因子：
5.4
作者：
Hadeiba, Husein;Butcher, Eugene C.
通讯作者：
Butcher, Eugene C.
DOI：
10.4049/jimmunol.1002276
发表时间：
2010-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chu HH;Moon JJ;Kruse AC;Pepper M;Jenkins MK
通讯作者：
Jenkins MK