Fully Customizable, Low-Cost, Multi-Contact Nerve Cuffs for Spatially Selective Neuromodulation
Fully Customizable, Low-Cost, Multi-Contact Nerve Cuffs for Spatially Selective Neuromodulation
复制标题
完全可定制、低成本、多接触神经袖带，用于空间选择性神经调节
DOI：
10.1109/embc40787.2023.10340814
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Johnson, Benjamin C.
中科院分区：
文献类型：
--
作者：
Riley, Morgan;Tala, FNU;Johnson, Katherine J.;Johnson, Benjamin C.
周围神经的选择性神经调节是对传统药物治疗有抗性的神经系统疾病的新兴治疗。虽然具有多通道刺激的神经袖带可以通过许多不同的方法制成，但它们通常需要专门的微加工或增材制造设备。一个真正的低成本和有效的方法来创建一个定制的袖带还没有访问的研究人员原型新的方法和治疗在急性研究。在这里，我们提出了一种廉价的，高度可重复的方法来创建多接触神经袖口，需要一个简单的后生产PEDOT：PSS涂层，以改善组织/电极界面。我们证明了空间选择性神经调制与建议袖口设计大鼠坐骨神经优先激活胫骨前肌（TA）和外侧腓肠肌（LG）的纵向和横向刺激模式。这表明所提出的袖带制造方法不仅对选择性神经调节有效，而且成本显著降低，完全可定制，并且易于制造，用于未来的选择性神经调节研究。
Selective neuromodulation of peripheral nerves is an emerging treatment for neurological diseases that are resistant to traditional drug therapy. While nerve cuffs with multichannel stimulation can be made by many varied methods, they usually require specialized microfabrication or additive manufacturing equipment. A truly low-cost and effective method of creating a custom cuff has not been accessible to researchers to prototype new methodologies and therapies in acute studies. Here, we present an inexpensive, highly repeatable method to create multi-contact nerve cuffs that require a simple postproduction PEDOT:PSS coating to improve the tissue/electrode interface. We demonstrate spatially selective neuromodulation with the proposed cuff design on the rat sciatic by preferentially activating the tibialis anterior (TA) and the lateral gastrocnemius (LG) in longitudinal and transverse stimulation patterns. This demonstrates that the proposed cuff fabrication method was not only effective for selective neuromodulation, but it is also significantly lower in cost, fully-customizable, and easily manufactured for future selective neuromodulation studies.
影响因子：
4.6
作者：
Bozkurt, Alper;Lal, Amit
通讯作者：
Lal, Amit
影响因子：
4.3
作者：
Flavin MT;Paul MA;Lim AS;Abdulhamed S;Lissandrello CA;Ajemian R;Lin SJ;Han J
通讯作者：
Han J