The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP.
The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP.
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DOI：
10.1016/j.neuron.2010.12.008
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发表时间：
2011-01-13
期刊：
影响因子：
16.2
通讯作者：
Tonegawa S
中科院分区：
文献类型：
--
作者：
Govindarajan A;Israely I;Huang SY;Tonegawa S
长时程增强（L-LTP）的晚期相，即长时程记忆的细胞相关物，在某些突触处诱导，促进在接受太弱而不能单独诱导L-LTP的刺激的其他突触处的L-LTP表达。使用谷氨酸释放和双光子成像，我们证明了这种促进的功效随着刺激之间的时间增加，刺激的棘之间的距离增加和棘在不同的树突状分支上而降低。有趣的是，如果在时间上刺激太接近，则刺激的棘竞争L-LTP表达。此外，这种促进作用在时间上是双向的，但不对称。此外，L-LTP形成本身偏向于发生在分支内的棘上。这些数据支持了“离散可塑性假说”，该假说指出，这种空间和时间限制导致稳定的记忆印迹形成，优先在树突分支内聚集的突触处，而不是分散在整个树突乔木中。因此，树突状分支而不是单个突触是长期记忆存储的主要功能单位。
The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased towards occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage.
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