Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.
Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.
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DOI：
10.1002/hbm.25945
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发表时间：
2022-09
影响因子：
4.8
通讯作者：
Geschwind, Michael D.
中科院分区：
文献类型：
--
作者：
Paoletti, Matteo;Caverzasi, Eduardo;Mandelli, Maria Luisa;Brown, Jesse A.;Henry, Roland G.;Miller, Bruce L.;Rosen, Howard J.;DeArmond, Stephen J.;Bastianello, Stefano;Seeley, William W.;Geschwind, Michael D.
灰质受累是散发性克雅氏病 (sCJD) 的一个众所周知的特征，但基于解剖学的扩散率降低的精确量化仍不完全清楚。最近已证明默认模式网络 (DMN) 区域选择性地参与了 sCJD，而功能连接从未在朊病毒疾病中进行过研究。我们使用定量多参数 MRI 方法分析了灰质受累情况。具体来说，采用分组方法将 37 名 sCJD 受试者的灰质平均扩散率与 30 名年龄匹配的健康对照者的灰质平均扩散率进行了比较。对于具有尸检数据的患者，还检查了 sCJD 皮质（MM(V)1、MM(V)2C 和 VV1）和皮质下（VV2 和 MV2K）亚组之间平均扩散率的差异（n = 27，73%）。我们还利用可用的 rs-fMRI 数据集（n = 17）评估了部分受试者中 DMN 腹侧和背侧部分的静息态功能连接。弥散性降低主要存在于 DMN 的后皮质区域，但除了广泛的深部核团受累外，还存在于 DMN 之外的颞区以及少数边缘和额叶区域。皮质下型和皮质型 sCJD 亚组均表现出皮质下扩散率降低，而只有皮质型型的皮质扩散率显着降低，主要出现在双侧顶叶、枕叶和内侧颞叶皮质。有趣的是，我们发现与健康对照相比，sCJD 受试者 DMN 的背侧和腹侧部分的连接性异常增加。功能成像作为追踪朊病毒疾病进展的生物标志物的重要性和可能的效用需要进一步探讨。在我们的研究中，我们定量探索了一组零星克雅氏受试者的灰质扩散性和静息态功能连接，并发现了默认模式网络中包含的区域的参与。定量扩散率和静止功能数据的结合可能为理解朊病毒疾病提供有用的新见解。
Grey matter involvement is a well‐known feature in sporadic Creutzfeldt–Jakob disease (sCJD), yet precise anatomy‐based quantification of reduced diffusivity is still not fully understood. Default Mode Network (DMN) areas have been recently demonstrated as selectively involved in sCJD, and functional connectivity has never been investigated in prion diseases. We analyzed the grey matter involvement using a quantitatively multi‐parametric MRI approach. Specifically, grey matter mean diffusivity of 37 subjects with sCJD was compared with that of 30 age‐matched healthy controls with a group‐wise approach. Differences in mean diffusivity were also examined between the cortical (MM(V)1, MM(V)2C, and VV1) and subcortical (VV2 and MV2K) subgroups of sCJD for those with autopsy data available (n = 27, 73%). We also assessed resting‐state functional connectivity of both ventral and dorsal components of DMN in a subset of subject with a rs‐fMRI dataset available (n = 17). Decreased diffusivity was predominantly present in posterior cortical regions of the DMN, but also outside of the DMN in temporal areas and in a few limbic and frontal areas, in addition to extensive deep nuclei involvement. Both subcortical and cortical sCJD subgroups showed decreased diffusivity subcortically, whereas only the cortical type expressed significantly decreased diffusivity cortically, mainly in parietal, occipital, and medial‐inferior temporal cortices bilaterally. Interestingly, we found abnormally increased connectivity in both dorsal and ventral components of the DMN in sCJD subjects compared with healthy controls. The significance and possible utility of functional imaging as a biomarker for tracking disease progression in prion disease needs to be explored further. In our study we explored quantitatively the diffusivity of grey matter and resting‐state functional connectivity in a cohort of sporadic Creutzfeldt‐Jakob subjects and found an involvement of areas included in the Default Mode Network. Combined quantitative diffusivity and functional data at rest may provide useful novel insights in the understanding of prion diseases.
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DOI：
10.1016/j.nicl.2014.01.011
发表时间：
2014
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Caverzasi E;Henry RG;Vitali P;Lobach IV;Kornak J;Bastianello S;Dearmond SJ;Miller BL;Rosen HJ;Mandelli ML;Geschwind MD
通讯作者：
Geschwind MD
影响因子：
34.7
作者：
Frost, Bess;Diamond, Marc I.
通讯作者：
Diamond, Marc I.
影响因子：
3.5
作者：
Cohen, Oren S.;Hoffmann, Chen;Prohovnik, Isak
通讯作者：
Prohovnik, Isak
影响因子：
29
作者：
Bizzi, Alberto;Pascuzzo, Riccardo;Gambetti, Pierluigi
通讯作者：
Gambetti, Pierluigi
影响因子：
4.2
作者：
Agosta, Federica;Canu, Elisa;Filippi, Massimo
通讯作者：
Filippi, Massimo