Metastases: the glycan connection.
Metastases: the glycan connection.
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DOI：
10.1186/bcr75
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Green JE
中科院分区：
文献类型：
--
作者：
Couldrey C;Green JE
蛋白质糖基化和肿瘤发生之间的关联已经被认识了10多年。糖基化事件的重要性与肿瘤生物学，特别是转移性疾病的进展之间的关联已被注意多年。最近，使用敲除β 1，6-N-乙酰葡糖胺转移酶V（N-聚糖途径中的限速酶）的小鼠模型来证明糖基化在肿瘤进展中的重要性。通过将缺乏这种酶的小鼠与转移性乳腺癌的转基因小鼠模型杂交，疾病的转移进展显着减少。这些实验为N-连接糖基化在转移性乳腺癌中的作用提供了体内证据，并对新治疗策略的开发具有重要意义。
An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to metastatic disease, have been noted over many years, Recently, a mouse model in which β1,6-N-acetylglucosaminyltransferase V (a rate-limiting enzyme in the N-glycan pathway) has been knocked out, was used to demonstrate the importance of glycosylation in tumor progression. By crossing mice lacking this enzyme with a transgenic mouse model of metastatic breast cancer, metastatic progression of the disease was dramatically reduced. These experiments provide in vivo evidence for the role of N-linked glycosylation in metastatic breast cancer and have significant implications for the development of new treatment strategies.
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影响因子：
5.3
作者：
GUY, CT;CARDIFF, RD;MULLER, WJ
通讯作者：
MULLER, WJ
影响因子：
45.3
作者：
Greenberg, PAC;Hortobagyi, GN;Buzdar, AU
通讯作者：
Buzdar, AU
影响因子：
56.9
作者：
WOOSTER, R;NEUHAUSEN, SL;STRATTON, MR
通讯作者：
STRATTON, MR
影响因子：
11.4
作者：
METZLER, M;GERTZ, A;MARTH, JD
通讯作者：
MARTH, JD
影响因子：
56.9
作者：
BUCK, CA;GLICK, MC;WARREN, L
通讯作者：
WARREN, L