Poly(ether sulfone) nanoparticles and controllably modified nanoparticles obtained through temperature-dependent cryogelation
Poly(ether sulfone) nanoparticles and controllably modified nanoparticles obtained through temperature-dependent cryogelation
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聚醚砜纳米颗粒和通过温度依赖性冷冻凝胶获得的可控改性纳米颗粒
DOI：
10.1002/app.47485
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发表时间：
2019-05
影响因子：
3
通讯作者：
Zhang Yukui
中科院分区：
文献类型：
--
作者：
Liu Lukuan;Yang Kaiguang;Li Senwu;Zhang Lihua;Zhang Yukui
聚醚砜（PES）纳米颗粒在纳米医学领域具有广阔的应用前景。然而，由于缺乏先进的设备，目前的技术还不能用于制造基于PES的NPs。在本研究中，开发了一种温度依赖的冷冻工艺，在不需要任何纳米制造设备或合成步骤的情况下，在异常低的聚合物浓度下通过PES自组装来制备PES NPs。制备的NPs的形貌随初始PES溶液浓度的不同而变化，聚合物颗粒的直径可达50 nm左右，具有较高的单分散性。此外，我们还探索了一种新的共冷方式，将两种具有代表性的可逆加成-破碎链转移（RAFT）剂分别引入到PES NPs上，以进行以下改性。然后，进行了表面引发的RAFT聚合，以实现NPs外聚合物刷的可控变化，以验证其进一步应用的可扩展性。©2019 Wiley期刊公司j:。变异较大。Sci.2019、136、47485。
Poly(ether sulfone) (PES) nanoparticles (NPs) have broad application prospects in the field of nanomedicine. However, the current techniques could not be used to create PES‐based NPs because of a lack of sophisticated equipment. In this study, a temperature‐dependent cryogelation process was developed to fabricate PES NPs through PES self‐assembly under unusually low polymer concentrations in the absence of any nanomanufacturing equipment or synthesis steps. The morphologies of the prepared NPs varied with the concentration difference of the initial PES solutions, and the diameter of the polymer particles reached about 50 nm with a high monodispersity. Furthermore, cocryogelation was explored in a novel manner to introduce two representative reversible addition−fragmentation chain‐transfer (RAFT) agents onto the PES NPs separately for the following modification. Then, surface‐initiated RAFT polymerization was also conducted to enable the controllable variation of the polymer brushes outside the NPs to verify their scalability for further application. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47485.
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影响因子：
3.4
作者：
Telma Barroso;R. Viveiros;M. Coelho;T. Casimiro;A. Rego;A. Aguiar-Ricardo
通讯作者：
Telma Barroso;R. Viveiros;M. Coelho;T. Casimiro;A. Rego;A. Aguiar-Ricardo
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9.5
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9.5
作者：
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通讯作者：
Haijun Yu;Yiming Cao;Guodong Kang;Jianhui Liu;Li Meng;Q. Yuan
影响因子：
4.9
作者：
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通讯作者：
Kaiguang Yang;Jianxi Liu;Senwu Li;Qinran Li;Qi Wu;Yuan Zhou;Qun Zhao;Nan Deng;Zhen Liang;Lihua Zhang;Yukui Zhang