Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement.
Compartmentalized calcium dynamics in a C. elegans interneuron encode head movement.
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DOI：
10.1038/nature11081
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发表时间：
2012-07-05
期刊：
影响因子：
64.8
通讯作者：
Zhang, Yun
中科院分区：
文献类型：
--
作者：
Hendricks, Michael;Ha, Heonick;Maffey, Nicolas;Zhang, Yun
将神经元活动限制在特定的亚细胞区域是扩展神经元计算特性的一种机制。虽然在几个系统中已经研究了区隔化活动的电路组织，但其细胞基础仍然难以捉摸。在这里，我们描述了秀丽隐杆线虫RIA中间神经元的区隔性活动，这些神经元与头部运动神经元表现出多个相互连接，并接受来自感觉通路的输入。我们发现RIA通过轴突区隔在亚细胞尺度上对头部运动进行空间编码。这种亚细胞轴突活动依赖于来自头部运动神经元的胆碱能输入，并与感官输入引起的谷氨酸依赖的全局同步活动同时存在和叠加。突触后，毒蕈碱乙酰胆碱受体（mAchR） GAR-3在RIA中通过动员细胞内钙储存来区隔轴突活动。区隔活动独立于同步活动调节运动行为。
Confining neuronal activity to specific subcellular regions is a mechanism for expanding the computational properties of neurons. While the circuit organization underlying compartmentalized activity has been studied in several systems, its cellular basis remains elusive. Here, we characterize compartmentalized activity in Caenorhabditis elegans RIA interneurons, which display multiple reciprocal connections to head motor neurons and receive input from sensory pathways. We show that RIA spatially encodes head movement on a subcellular scale through axonal compartmentalization. This subcellular axonal activity is dependent on cholinergic input from head motor neurons and is simultaneously present and additive with glutamate-dependent globally synchronized activity evoked by sensory inputs. Postsynaptically, the muscarinic acetylcholine receptor (mAchR) GAR-3 acts in RIA to compartmentalize axonal activity through mobilization of intracellular calcium stores. The compartmentalized activity functions independently from the synchronized activity to modulate locomotory behavior.
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影响因子：
64.8
作者：
Euler, T;Detwiler, PB;Denk, W
通讯作者：
Denk, W
影响因子：
5.3
作者：
RALL, W;SHEPHERD, GM;BRIGHTMAN, MW
通讯作者：
BRIGHTMAN, MW
DOI：
10.1016/s0006-291x(03)01508-0
发表时间：
2003-09-05
影响因子：
3.1
作者：
Park, YS;Kim, S;Cho, NJ
通讯作者：
Cho, NJ
影响因子：
16.2
作者：
Ha, Heon-ick;Hendricks, Michael;Shen, Yu;Gabel, Christopher V.;Fang-Yen, Christopher;Qin, Yuqi;Colon-Ramos, Daniel;Shen, Kang;Samuel, Aravinthan D. T.;Zhang, Yun
通讯作者：
Zhang, Yun
影响因子：
4.3
作者：
Varshney LR;Chen BL;Paniagua E;Hall DH;Chklovskii DB
通讯作者：
Chklovskii DB