Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans.
Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans.
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DOI：
10.1038/s41398-021-01745-5
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发表时间：
2021-12-13
影响因子：
6.8
通讯作者：
Kaufer D
中科院分区：
文献类型：
--
作者：
Long KLP;Chao LL;Kazama Y;An A;Hu KY;Peretz L;Muller DCY;Roan VD;Misra R;Toth CE;Breton JM;Casazza W;Mostafavi S;Huber BR;Woodward SH;Neylan TC;Kaufer D
个体对创伤应激的反应差异很大，但这种差异的生物学基础仍然知之甚少。最近的研究表明，在压力和经历的作用下，少突胶质细胞和髓鞘具有惊人的可塑性，这为创伤导致成人大脑结构和功能的异常变化提供了一种潜在的机制。在这项研究中，我们使用一种翻译方法来检验灰质少突胶质细胞对创伤应激诱导的大鼠和人类的行为差异有贡献的假设。我们将成年雄性大鼠暴露在单一的严重应激源下，并使用多模式方法来表征回避、惊吓和恐惧学习行为，以及多个脑区的少突胶质细胞和髓鞘碱性蛋白(MBP)含量。我们发现少突胶质细胞密度和MBP以区域特有的方式与行为结果相关。具体地说，应激诱导的回避与海马齿状回少突胶质细胞和MBP呈正相关。在齿状回病毒过表达的寡树突状细胞因子Orig1足以诱导焦虑样行为表型。相比之下，背景恐惧学习与杏仁核和海马体空间处理区域的MBP呈正相关。在一组暴露于创伤的美国退伍军人中，对海马体和杏仁体髓鞘的T1/T2加权磁共振成像估计与特定区域的症状相关联，反映了在大鼠身上的发现。这些结果表明，创伤应激暴露后，特定区域的灰质少突胶质细胞和不同的行为表型之间存在独立于物种的关系。这项研究提出了一种新的大脑可塑性机制，这种机制是个体对创伤应激敏感性差异的基础。
Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate the surprising plasticity of oligodendrocytes and myelin with stress and experience, providing a potential mechanism by which trauma induces aberrant structural and functional changes in the adult brain. In this study, we utilized a translational approach to test the hypothesis that gray matter oligodendrocytes contribute to traumatic-stress-induced behavioral variation in both rats and humans. We exposed adult, male rats to a single, severe stressor and used a multimodal approach to characterize avoidance, startle, and fear-learning behavior, as well as oligodendrocyte and myelin basic protein (MBP) content in multiple brain areas. We found that oligodendrocyte cell density and MBP were correlated with behavioral outcomes in a region-specific manner. Specifically, stress-induced avoidance positively correlated with hippocampal dentate gyrus oligodendrocytes and MBP. Viral overexpression of the oligodendrogenic factor Olig1 in the dentate gyrus was sufficient to induce an anxiety-like behavioral phenotype. In contrast, contextual fear learning positively correlated with MBP in the amygdala and spatial-processing regions of the hippocampus. In a group of trauma-exposed US veterans, T1-/T2-weighted magnetic resonance imaging estimates of hippocampal and amygdala myelin associated with symptom profiles in a region-specific manner that mirrored the findings in rats. These results demonstrate a species-independent relationship between region-specific, gray matter oligodendrocytes and differential behavioral phenotypes following traumatic stress exposure. This study suggests a novel mechanism for brain plasticity that underlies individual variance in sensitivity to traumatic stress.
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影响因子：
7.7
作者：
Bonnefil, Valentina;Dietz, Karen;Liu, Jia
通讯作者：
Liu, Jia
影响因子：
6.8
作者：
Cohen, Shlomi;Matar, Michael A.;Cohen, Hagit
通讯作者：
Cohen, Hagit
影响因子：
5.3
作者：
Falkai, Peter;Steiner, Johann;Schmitt, Andrea
通讯作者：
Schmitt, Andrea
不良包裹：健康和疾病中的髓磷脂和髓鞘可塑性。
影响因子：
3
作者：
Gibson EM;Geraghty AC;Monje M
通讯作者：
Monje M
影响因子：
3
作者：
Chao LL;Tosun D;Woodward SH;Kaufer D;Neylan TC
通讯作者：
Neylan TC