Projection imaging of photon beams using Čerenkov-excited fluorescence.
Projection imaging of photon beams using Čerenkov-excited fluorescence.
复制标题
使用切伦科夫激发荧光的光子束投影成像。
DOI：
10.1088/0031-9155/58/3/601
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发表时间：
2013-02-07
影响因子：
3.5
通讯作者：
Gladstone DJ
中科院分区：
文献类型：
--
作者：
Glaser AK;Davis SC;Voigt WH;Zhang R;Pogue BW;Gladstone DJ
由于传统扫描电离室系统逐点测量的缓慢特性，治疗性超压直线加速器（LINAC） x射线光子束的全三维光束分析和质量保证（QA）并没有常规进行。在这项研究中，我们探索了一种新的基于光学的剂量成像方法，该方法使用标准的商用相机，水箱和荧光染料，当被辐射光束引起的Čerenkov发射激发时，可以在快速的时间框架内进行2D投影成像，有可能导致3D层析成像光束剖面。对实验装置的成像参数进行了详细的优化分析。结果表明，捕获的图像与剂量呈线性关系，与剂量率无关，并且将实验捕获的图像与4×4 cm 6 MV x射线光子束的参考剂量分布进行比较，所得结果比先前使用Čerenkov发射本身的直接成像和蒙特卡罗校准的研究结果精度更高。横向与参考剂量分布的一致性在1-2%以内，深度与参考剂量分布的一致性在±3%以内。该研究仅限于单个2D图像投影，最终目标是在多个投影的层析成像重建后创建完整的3D剖面。鉴于放射治疗日益复杂的进展，以及对患者特异性治疗计划的日益重视，该技术的进一步改进可能被证明是快速和强大的x射线光子LINAC光束质量保证的重要工具。
Full 3D beam profiling and quality assurance (QA) of therapeutic megavoltage linear accelerator (LINAC) x-ray photon beams is not routinely performed due to the slow point-by-point measurement nature of conventional scanning ionization chamber systems. In this study we explore a novel optical-based dose imaging approach using a standard commercial camera, water tank, and fluorescent dye, which when excited by the Čerenkov emission induced by the radiation beam, allows 2D projection imaging in a fast timeframe, potentially leading towards 3D tomographic beam profiling. Detailed analysis was done to optimize the imaging parameters in the experimental setup. The results demonstrate that the captured images are linear with delivered dose, independent of dose rate, and comparison of experimentally captured images to a reference dose distribution for a 4×4 cm 6 MV x-ray photon beam yielded results with improved accuracy over a previous study which used direct imaging and Monte Carlo calibration of the Čerenkov emission itself. The agreement with the reference dose distribution was within 1-2% in the lateral direction, and ± 3 % in the depth direction. The study was restricted to single 2D image projection, with the eventual goal of creating full 3D profiles after tomographic reconstruction from multiple projections. Given the increasingly complex advances in radiation therapy, and the increased emphasis on patient-specific treatment plans, further refinement of the technique could prove to be an important tool for fast and robust QA of x-ray photon LINAC beams.
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