Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping.
Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping.
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通过心血管磁共振天然 T1 映射对杜氏肌营养不良症心肌受累进行整体、节段和分层特异性分析
DOI：
10.1186/s12968-021-00802-8
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发表时间：
2021-10-14
期刊：
影响因子：
--
通讯作者：
Guo YK
中科院分区：
文献类型：
--
作者：
Xu K;Xu HY;Xu R;Xie LJ;Yang ZG;Yu L;Zhou B;Fu H;Liu H;Cai XT;Guo YK
进行性心肌病几乎是杜氏肌营养不良症（DMD）患者所有死亡的原因。因此，我们的目的是通过研究DMD患者本地T1映射的异质性，在一个大的队列中使用全球和区域（包括节段性和层特异性）分析，全面表征心肌受累。我们前瞻性招募了99名DMD患者（8.8 ± 2.5岁）和25名匹配的男性健康对照（9.5 ± 2.5岁）。所有受试者均接受了心血管磁共振（CMR）电影、T1标测和晚期钆增强（LGE）序列。测量基于整体和局部心肌的天然T1值，并定义LGE。49例（49%）DMD患者存在LGE。LGE阳性（LGE +）患者的整体天然T1值显著长于健康对照组，在基底层（1304 ± 55 vs. 1246 ± 27 ms，p < 0.001）和中层层（1305 ± 57 vs. 1245 ± 37 ms，p < 0.001）。在健康对照组和LGE阴性（LGE−）患者之间未发现整体天然T1的显著差异。在节段分析中，与健康对照组相比，LGE +患者在所有分析节段中的天然T1均显著增加。同时，LGE−患者和健康对照组之间的比较显示，仅基底前外侧段的值显著升高（1273 ± 62 vs. 1234 ± 40 ms，p = 0.034）。有趣的是，LGE−患者的心外膜层的天然T1显著高于健康对照组（p < 0.05），而在整体心肌中没有观察到这种模式。与整体天然T1和内膜层天然T1相比，心外膜层天然T1在受试者工作曲线分析中区分健康对照和DMD患者的诊断性能最高（基线水平的曲线下面积[AUC]为0.84，中间水平为0.85）。心肌局部固有T1，特别是心外膜固有T1，似乎有潜力作为DMD患者极早期心脏受累的一种新的可靠标志物。试验注册：中国临床试验注册中心（http：//www.chictr.org.cn/index.aspx）ChiCTR 1800018340，09/12/2018，Retroperoxidase注册。
Progressive cardiomyopathy accounts for almost all mortality among Duchenne muscular dystrophy (DMD) patients. Thus, our aim was to comprehensively characterize myocardial involvement by investigating the heterogeneity of native T1 mapping in DMD patients using global and regional (including segmental and layer-specific) analysis across a large cohort. We prospectively enrolled 99 DMD patients (8.8 ± 2.5 years) and 25 matched male healthy controls (9.5 ± 2.5 years). All subjects underwent cardiovascular magnetic resonance (CMR) with cine, T1 mapping and late gadolinium enhancement (LGE) sequences. Native T1 values based on the global and regional myocardium were measured, and LGE was defined. LGE was present in 49 (49%) DMD patients. Global native T1 values were significantly longer in LGE-positive (LGE +) patients than in healthy controls, both in basal slices (1304 ± 55 vs. 1246 ± 27 ms, p < 0.001) and in mid-level slices (1305 ± 57 vs. 1245 ± 37 ms, p < 0.001). No significant difference in global native T1 was found between healthy controls and LGE-negative (LGE−) patients. In segmental analysis, LGE + patients had significantly increased native T1 in all analyzed segments compared to the healthy control group. Meanwhile, the comparison between LGE− patients and healthy controls showed significantly elevated values only in the basal anterolateral segment (1273 ± 62 vs. 1234 ± 40 ms, p = 0.034). Interestingly, the epicardial layer had a significantly higher native T1 in LGE− patients than in healthy controls (p < 0.05), whereas no such pattern was noticed in the global myocardium. Epicardial layer native T1 resulted in the highest diagnostic performance for distinguishing between healthy controls and DMD patients in receiver operating curve analyses (area under the curve [AUC] 0.84 for basal level and 0.85 for middle level) when compared to global native T1 and endocardial layer native T1. Myocardial regional native T1, particularly epicardial native T1, seems to have potential as a novel robust marker of very early cardiac involvement in DMD patients. Trial registration: Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) ChiCTR1800018340, 09/12/2018, Retrospectively registered.
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影响因子：
37.8
作者：
McNally EM;Kaltman JR;Benson DW;Canter CE;Cripe LH;Duan D;Finder JD;Groh WJ;Hoffman EP;Judge DP;Kertesz N;Kinnett K;Kirsch R;Metzger JM;Pearson GD;Rafael-Fortney JA;Raman SV;Spurney CF;Targum SL;Wagner KR;Markham LW;Working Group of the National Heart, Lung, and Blood Institute;Parent Project Muscular Dystrophy
通讯作者：
Parent Project Muscular Dystrophy
DOI：
10.1186/s12968-016-0308-4
发表时间：
2016-11-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Haaf P;Garg P;Messroghli DR;Broadbent DA;Greenwood JP;Plein S
通讯作者：
Plein S
影响因子：
24
作者：
Silva, Marly Conceicao;Meira, Zilda Maria Alves;Rochitte, Carlos Eduardo
通讯作者：
Rochitte, Carlos Eduardo
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
8
作者：
Buddhe, Sujatha;Cripe, Linda;Olson, Aaron K.
通讯作者：
Olson, Aaron K.