Determinants of protection among HIV‐exposed seronegative persons: an overview.
Determinants of protection among HIV‐exposed seronegative persons: an overview.
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DOI：
10.1086/655967
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发表时间：
2010-11-01
期刊：
影响因子：
--
通讯作者：
Goedert JJ
中科院分区：
文献类型：
--
作者：
Lederman MM;Alter G;Daskalakis DC;Rodriguez B;Sieg SF;Hardy G;Cho M;Anthony D;Harding C;Weinberg A;Silverman RH;Douek DC;Margolis L;Goldstein DB;Carrington M;Goedert JJ
临床经验和越来越多的医学文献都表明，有些人接触过艾滋病毒感染，但仍然没有受到感染。虽然在某些情况下，这可能意味着好运，但据报告，在未感染人群中，感染风险被认为很高。在这些群体中，已经提出了多种特征作为介导保护，但迄今为止，只有导致该共受体的细胞表面表达完全失败的CCR 5基因中的32个碱基对缺失与对HIV感染的高水平保护相关。考虑到这一点，可能还有许多其他因素可以单独或组合提供某种程度的保护，防止艾滋病毒感染。由于其中一些因素可能不完全具有保护性或不一贯地活跃，因此很难有信心地确定它们。尽管如此，澄清保护免受艾滋病毒感染的决定因素是一个高度优先事项，这将需要仔细选择高风险的未感染的队列，有针对性的研究合理的介质和广泛的筛选意外的保护决定因素应适用。
Both clinical experience and a growing medical literature indicate that there are persons who have been exposed to HIV infection who have remained uninfected. While in some instances this may represent good fortune, cohorts of uninfected persons have been reported where risks for infection are thought to be high. In these cohorts a variety of characteristics have been proposed as mediating protection but to date only the 32 base pair deletion in the CCR5 gene that results in complete failure of cell surface expression of this co-receptor has been associated with high level protection from HIV infection. With this in mind, there are likely numerous other factors that may individually or in combination provide some level of protection from acquisition of HIV infection. As some of these factors are likely incompletely protective or inconsistently active, identifying them with confidence will be difficult. Nonetheless, clarifying the determinants of protection against HIV infection is a high priority that will require careful selection of high risk uninfected cohorts to which targeted studies of plausible mediators and broad screening for unexpected determinants of protection should be applied.
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