A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade.
A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade.
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中国HIV-1 CRF07_BC新迁移图：十年来12个省的序列分析
DOI：
10.1371/journal.pone.0052373
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Meng Z;Xin R;Zhong P;Zhang C;Abubakar YF;Li J;Liu W;Zhang X;Xu J
Background As one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstructing transmission map. Meanwhile, ample historic epidemic evidences were also reviewed to assist sequences analysis. Methodology/Principal Findings In the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999–2001. These analyzed results are in accordance with early epidemic investigations. Conclusions/Significance Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China.
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影响因子：
11.8
作者：
Garten, RJ;Zhang, JB;Yu, XF
通讯作者：
Yu, XF
血浆中中国HIV-1毒株B和BC亚型病毒体基因组测序的新方法
影响因子：
6.1
作者：
Meng Zhe-feng;Zhang Xiao-yan;Shao Yi-ming
通讯作者：
Shao Yi-ming
影响因子：
3.7
作者：
Esbjörnsson J;Mild M;Månsson F;Norrgren H;Medstrand P
通讯作者：
Medstrand P
影响因子：
4.3
作者：
Lemey P;Rambaut A;Drummond AJ;Suchard MA
通讯作者：
Suchard MA
影响因子：
5.4
作者：
Piyasirisilp, S;McCutchan, FE;Yu, XF
通讯作者：
Yu, XF