Real-time fMRI applied to pain management.
Real-time fMRI applied to pain management.
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DOI：
10.1016/j.neulet.2012.02.076
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发表时间：
2012-06-29
影响因子：
2.5
通讯作者：
Mackey S
中科院分区：
文献类型：
--
作者：
Chapin H;Bagarinao E;Mackey S
目前的观点认为，大脑在疼痛体验的产生和维持中起着关键作用。实时功能磁共振成像（rtfMRI）反馈是一种潜在的疼痛调制工具，直接针对大脑恢复调节功能的目标。虽然仍然相对较新，但rtfMRI是一项快速发展的技术，在过去的15年里，它已经从简单的概念验证实验发展到对单个和多个大脑区域的学习控制的演示。大量研究表明，rtfMRI反馈辅助控制特定的大脑区域可能有应用，包括情绪调节，语言处理，神经康复中风，增强感知和学习，疼痛管理。我们详细讨论了我们实验室早期的工作，其中rtfMRI反馈用于训练健康对照组和慢性疼痛患者调节前扣带皮层（ACC）激活，以改变疼痛体验。通过rtfMRI反馈训练，两组患者控制ACC激活和调节疼痛的能力都有所提高。此外，参与者能够调节疼痛的程度与对ACC激活的控制程度相关。我们还回顾了rtfMRI反馈的当前进展，如实时模式分类，使该技术更接近于更全面的控制神经功能。最后，剩余的方法论问题有关的进一步发展rtfMRI反馈及其对未来的疼痛研究的影响进行了讨论。
Current views recognize the brain as playing a pivotal role in the arising and maintenance of pain experience. Real-time fMRI (rtfMRI) feedback is a potential tool for pain modulation that directly targets the brain with the goal of restoring regulatory function. Though still relatively new, rtfMRI is a rapidly developing technology that has evolved in the last 15 years from simple proof of concept experiments to demonstrations of learned control of single and multiple brain areas. Numerous studies indicate rtfMRI feedback assisted control over specific brain areas may have applications including mood regulation, language processing, neurorehabilitation in stroke, enhancement of perception and learning, and pain management. We discuss in detail earlier work from our lab in which rtfMRI feedback was used to train both healthy controls and chronic pain patients to modulate anterior cingulate cortex (ACC) activation for the purposes of altering pain experience. Both groups improved in their ability to control ACC activation and modulate their pain with rtfMRI feedback training. Furthermore, the degree to which participants were able to modulate their pain correlated with the degree of control over ACC activation. We additionally review current advances in rtfMRI feedback, such as real-time pattern classification, that bring the technology closer to more comprehensive control over neural function. Finally, remaining methodological questions concerning the further development of rtfMRI feedback and its implications for the future of pain research are also discussed.
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影响因子：
3.7
作者：
Brown JE;Chatterjee N;Younger J;Mackey S
通讯作者：
Mackey S
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
10.6
作者：
Caria, Andrea;Sitaram, Ranganatha;Birbaumer, Niels
通讯作者：
Birbaumer, Niels
影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
Tracey, I
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ