Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats.
Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats.
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DOI：
10.1155/2013/830684
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Oda H
中科院分区：
文献类型：
--
作者：
Laurent T;Okuda Y;Chijimatsu T;Umeki M;Kobayashi S;Kataoka Y;Tatsuguchi I;Mochizuki S;Oda H
淡水蛤（Corbicula spp.）是一种受欢迎的可食用双壳类动物，在亚洲被用作肝病的民间疗法。作为一种中国传统药物，据说淡水蛤可以改善酒精中毒和胆汁淤积。在这项研究中，以评估淡水蛤提取物（FCE）的实际效益，我们比较了FCE和大豆分离蛋白（SPI）对大鼠甘油三酯和胆固醇代谢的影响。FCE和SPI降低血清胆固醇，FCE倾向于降低血清甘油三酯。FCE增强粪便固醇排泄和肝脏CYP 7A 1和ABCG 5的mRNA水平比SPI更显著;然而，两种饮食都降低了肝脏胆固醇。两种饮食类似地抑制了肝脏脂质，改善了Δ9-去饱和脂肪酸谱，并且FCE与FAS和SCD 1 mRNA水平的降低相关。肝脏转录组分析显示，脂肪生成相关基因表达的抑制可能有助于FCE下调肝脏甘油三酯。FCE可能通过类似于SPI的机制，通过更大程度地改善甘油三酯和胆固醇的代谢，对预防代谢紊乱具有更好的潜在益处。
The freshwater clam (Corbicula spp.) is a popular edible bivalve and has been used as a folk remedy for liver disease in Asia. As a Chinese traditional medicine, it is said that freshwater clam ameliorates alcoholic intoxication and cholestasis. In this study, to estimate the practical benefit of freshwater clam extract (FCE), we compared the effects of FCE and soy protein isolate (SPI) on triglyceride and cholesterol metabolism in rats. FCE and SPI lowered serum cholesterol, and FCE tended to reduce serum triglycerides. FCE enhanced fecal sterol excretion and hepatic mRNA levels of CYP7A1 and ABCG5 more substantially than SPI; however, both diets reduced hepatic cholesterol. Both of the diets similarly suppressed liver lipids improved Δ9-desaturated fatty acid profile, and FCE was associated with a reduction in FAS and SCD1 mRNA levels. Hepatic transcriptome analysis revealed that inhibition of lipogenesis-related gene expression may contribute to downregulation of hepatic triglycerides by FCE. FCE would have better potential benefits for preventing metabolic disorders, through greater improvement of metabolism of triglycerides and cholesterol, likely through a mechanism similar to SPI.
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影响因子：
4.2
作者：
Ascencio, C;Torres, N;Tovar, AR
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