Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma.
Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma.
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鉴定 4 种免疫细胞和 5-lncRNA 风险特征与早期肺腺癌的预后
DOI：
10.1186/s12967-021-02800-x
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发表时间：
2021-03-26
影响因子：
7.4
通讯作者：
Yang W
中科院分区：
文献类型：
--
作者：
Mu L;Ding K;Tu R;Yang W
肺癌是全球最常见的癌症，也是导致癌症相关死亡的原因，越来越多的证据表明肿瘤与长链非编码RNA（lncRNA）以及肿瘤免疫浸润之间存在显着相关性，但其在早期肺腺癌（LUAD）中的作用仍不清楚。从GEO和TCGA数据库下载早期LUAD患者的基因表达数据和相应的临床数据。通过数量分析和单变量cox回归分析对24种肿瘤浸润免疫细胞进行分析，利用共识聚类将患者分为两个亚组，识别亚组中的差异表达基因（DEG），然后通过最小绝对收缩和选择算子（LASSO）回归建立lncRNA风险特征。本研究共有 718 名患者入组，其中 246 名患者来自 GSE31210 数据集，127 名患者来自 GSE50081 数据集，345 名患者来自 TCGA-LUAD。我们发现Th2细胞、TFH、NK CD56dim细胞和肥大细胞与预后相关（p < 0.05），然后建立了5-lncRNA风险特征（风险评分 = 0.374600616* LINC00857 + 0.173825706* LINC01116 + (− 0.021398903)* DRAIC + (− 0.113658256)* LINC01140 + (− 0.008403702)* XIST)，并绘制列线图，表明签名具有良好的预测精度和辨别力。我们鉴定了 4 个与早期 LUAD 预后相关的免疫浸润细胞，并建立了一个新的 5 个免疫相关 lncRNA 特征来预测患者的预后。
Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNAs), as well as tumor immune infiltration, but their role in early lung adenocarcinoma (LUAD) are still unclear. Gene expression data and corresponding clinical data of early-stage LUAD patients were downloaded from GEO and TCGA databases. 24 kinds of tumor-infiltrating immune cells were analyzed by quantity analysis and univariate cox regression analysis, we divided patients into two subgroups using consensus clustering, recognized the differentially expressed genes (DEGs) in the subgroups, then, established lncRNA risk signature by least absolute shrinkage and selection operator (LASSO) regression. A total of 718 patients were enrolled in this study, including 246 from GSE31210 dataset, 127 from GSE50081 dataset and 345 from TCGA-LUAD. We identified that Th2 cells, TFH, NK CD56dim cells and Mast cells were prognosis-related(p < 0.05), then established a 5-lncRNA risk signature (risk score = 0.374600616* LINC00857 + 0.173825706* LINC01116 + (− 0.021398903)* DRAIC + (− 0.113658256)* LINC01140 + (− 0.008403702)* XIST), and draw a nomogram showed that the signature had a well prediction accuracy and discrimination. We identified 4 immune infiltrating cells related to the prognosis of early-stage LUAD, and established a novel 5 immune-related lncRNA signature for predicting patients’ prognosis.
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影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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