Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults.
Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults.
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DOI：
10.3389/fneur.2022.1012668
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发表时间：
2022
影响因子：
3.4
通讯作者：
Miglis, Mitchell G.
中科院分区：
文献类型：
--
作者：
Larsen, Nicholas W.;Stiles, Lauren E.;Shaik, Ruba;Schneider, Logan;Muppidi, Srikanth;Tsui, Cheuk To;Geng, Linda N.;Bonilla, Hector;Miglis, Mitchell G.
关键词：
自主神经功能障碍是SARS-CoV-2(PASC)/Long COVID急性后遗症的已知并发症，但其患病率和严重程度尚不清楚。评估PASC自主神经功能障碍的频率、严重程度和危险因素，并确定急性SARS-CoV-2感染的严重程度是否与自主神经功能障碍的严重程度相关。对2020年10月至2021年8月期间通过Long CoVID支持小组招募的患有PASC的成年人进行横断面在线调查。2,413名年龄在18岁-之间的PASC成年人，包括新冠肺炎检测呈阳性(检测确认)的患者和仅基于临床症状被诊断为新冠肺炎的患者。主要结果测量是综合自主神经症状31(COMPASS-31)总分，用于评估全球自主神经功能障碍。对检测确认的住院患者和检测确认的非住院患者进行比较，以确定急性SARS-CoV-2感染的严重程度是否与严重的自主神经功能障碍有关。66%的PASC患者的COMPASS-31评分和20分提示中度到重度自主神经功能障碍。COMPASS-31得分在测试确认住院和测试确认非住院参与者之间没有差异[28.95(15.62，46.60)比26.4(13.75，42.10)；p=0.06]。在我们的研究中，66%的PASC患者有中到重度自主神经功能障碍的证据，这与住院状态无关，表明自主神经功能障碍在PASC人群中非常普遍，与急性新冠肺炎疾病的严重程度无关。
Autonomic dysfunction is a known complication of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID, however prevalence and severity are unknown. To assess the frequency, severity, and risk factors of autonomic dysfunction in PASC, and to determine whether severity of acute SARS-CoV-2 infection is associated with severity of autonomic dysfunction. Cross-sectional online survey of adults with PASC recruited through long COVID support groups between October 2020 and August 2021. 2,413 adults ages 18–64 years with PASC including patients who had a confirmed positive test for COVID-19 (test-confirmed) and participants who were diagnosed with COVID-19 based on clinical symptoms alone. The main outcome measure was the Composite Autonomic Symptom 31 (COMPASS-31) total score, used to assess global autonomic dysfunction. Test-confirmed hospitalized vs. test-confirmed non-hospitalized participants were compared to determine if the severity of acute SARS-CoV-2 infection was associated with the severity autonomic dysfunction. Sixty-six percent of PASC patients had a COMPASS-31 score >20, suggestive of moderate to severe autonomic dysfunction. COMPASS-31 scores did not differ between test-confirmed hospitalized and test-confirmed non-hospitalized participants [28.95 (15.62, 46.60) vs. 26.4 (13.75, 42.10); p = 0.06]. Evidence of moderate to severe autonomic dysfunction was seen in 66% of PASC patients in our study, independent of hospitalization status, suggesting that autonomic dysfunction is highly prevalent in the PASC population and independent of the severity of acute COVID-19 illness.
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影响因子：
13.6
作者：
Anaya JM;Rojas M;Salinas ML;Rodríguez Y;Roa G;Lozano M;Rodríguez-Jiménez M;Montoya N;Zapata E;Post-COVID study group;Monsalve DM;Acosta-Ampudia Y;Ramírez-Santana C
通讯作者：
Ramírez-Santana C
影响因子：
9.3
作者：
Pretorius E;Vlok M;Venter C;Bezuidenhout JA;Laubscher GJ;Steenkamp J;Kell DB
通讯作者：
Kell DB
DOI：
10.1016/j.jaccas.2021.01.009
发表时间：
2021-04
期刊：
JACC. Case reports
影响因子：
--
作者：
Johansson M;Ståhlberg M;Runold M;Nygren-Bonnier M;Nilsson J;Olshansky B;Bruchfeld J;Fedorowski A
通讯作者：
Fedorowski A
影响因子：
5.8
作者：
Kaufmann, Horacio;Malamut, Richard;Freeman, Roy
通讯作者：
Freeman, Roy
影响因子：
8.9
作者：
Sletten, David M.;Suarez, Guillermo A.;Singer, Wolfgang
通讯作者：
Singer, Wolfgang