Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.
Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.
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食管和食管癌的相差 X 射线 CT 成像
DOI：
10.1038/srep05332
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发表时间：
2014-06-18
影响因子：
4.6
通讯作者：
Su M
中科院分区：
文献类型：
--
作者：
Zhang J;Tian D;Lin R;Zhou G;Peng G;Su M
同步辐射相位衬度CT成像的电子密度分辨率比传统的X射线吸收成像高1000倍，可以实现生物软组织的高分辨率X射线成像。在本研究中，我们使用相位对比X线CT研究人类切除的食管和食管癌标本。这项技术揭示了食管壁的三层结构-粘膜层、粘膜下层和肌层。粘膜层和肌肉层被蜂窝状的松散粘膜下层清楚地分开。粘膜层表面光滑。在食管癌中，由于肿瘤组织浸润，粘膜下层缺失，这表明粘膜下层被破坏。正常组织与肿瘤的分界较模糊，食管壁的三层结构不清。粘膜层表面有皱纹。该技术可能有助于食管癌的分期。
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.
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