Evidence of inflammatory system involvement in Parkinson's disease.
Evidence of inflammatory system involvement in Parkinson's disease.
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DOI：
10.1155/2014/308654
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发表时间：
2014
影响因子：
--
通讯作者：
Tan EK
中科院分区：
文献类型：
--
作者：
Chao Y;Wong SC;Tan EK
帕金森病（Parkinson's disease，PD）是一种由遗传和环境因素共同作用的慢性神经退行性疾病。最近的研究结果表明，炎症可能是发病和进展的家族性和散发性PD的致病因素。了解炎症因子在PD中的确切作用可能有助于了解疾病是如何发生的。PD炎症的体内证据包括失调的分子介质，如细胞因子、补体系统及其受体、常驻小胶质细胞活化、外周免疫细胞侵袭以及外周免疫细胞的组成和表型改变。对这些因素的认识不断提高，促使人们采用新的方法来调节免疫系统，尽管这些方法是否可以用于人类仍然存在争议。老化和差异暴露于环境因子的影响表明潜在的宿主-病原体特异性病理生理因素。有一个明确的需要进行研究，以进一步揭示免疫在PD中的病理生理作用，并有可能为这种衰弱的疾病开发新的治疗靶点。
Parkinson's disease (PD) is a chronic neurodegenerative disease underpinned by both genetic and environmental etiologic factors. Recent findings suggest that inflammation may be a pathogenic factor in the onset and progression of both familial and sporadic PD. Understanding the precise role of inflammatory factors in PD will likely lead to understanding of how the disease arises. In vivo evidence for inflammation in PD includes dysregulated molecular mediators such as cytokines, complement system and its receptors, resident microglial activation, peripheral immune cells invasion, and altered composition and phenotype of peripheral immune cells. The growing awareness of these factors has prompted novel approaches to modulate the immune system, although it remains whether these approaches can be used in humans. Influences of ageing and differential exposure to environmental agents suggest potential host-pathogen specific pathophysiologic factors. There is a clear need for research to further unravel the pathophysiologic role of immunity in PD, with the potential of developing new therapeutic targets for this debilitating condition.
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