The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.
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DOI：
10.1111/acel.12746
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发表时间：
2018-06
期刊：
影响因子：
7.8
通讯作者：
Demaria M
中科院分区：
文献类型：
--
作者：
Fontana L;Mitchell SE;Wang B;Tosti V;van Vliet T;Veronese N;Bertozzi B;Early DS;Maissan P;Speakman JR;Demaria M
卡路里限制（CR）是一种有效的策略，以延缓老化表型的发生和进展在各种生物体。几个分子参与者参与了CR的抗衰老作用，但其调控机制尚不清楚。细胞衰老——一种不可逆生长停滞的细胞状态——被认为是衰老的基本机制。衰老细胞随着年龄的增长而积累，并促进许多与年龄相关的病理。饮食等环境条件是否会影响细胞衰老随年龄增长的积累尚不清楚。在这里，我们发现，在CR下，成年小鼠和相对年轻的小鼠衰老细胞的经典转录组标记物减少。此外，我们证明，与年龄匹配的正常西方饮食的志愿者相比，CR下中年人类志愿者的结肠中这些衰老标记物没有被诱导。我们的数据支持这样一种观点，即在CR下观察到的不同生物体健康寿命的改善可能部分是由于衰老细胞数量的减少。
Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti‐aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence—a cellular state of irreversible growth arrest—is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age‐related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle‐age human volunteers under CR in comparison with age‐matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.
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影响因子：
7.7
作者：
Schafer MJ;White TA;Evans G;Tonne JM;Verzosa GC;Stout MB;Mazula DL;Palmer AK;Baker DJ;Jensen MD;Torbenson MS;Miller JD;Ikeda Y;Tchkonia T;van Deursen JM;Kirkland JL;LeBrasseur NK
通讯作者：
LeBrasseur NK
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L
影响因子：
3.7
作者：
HAYFLICK, L;MOORHEAD, PS
通讯作者：
MOORHEAD, PS
影响因子：
11.8
作者：
Demaria, Marco;Ohtani, Naoko;Youssef, Sameh A.;Rodier, Francis;Toussaint, Wendy;Mitchell, James R.;Laberge, Remi-Martin;Vijg, Jan;Van Steeg, Harry;Dolle, Martijn E. T.;Hoeijmakers, Jan H. J.;de Bruin, Alain;Hara, Eiji;Campisi, Judith
通讯作者：
Campisi, Judith