A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention.

A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention.
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DOI:
10.1016/j.pscychresns.2012.10.011
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发表时间:
2012-11-30
影响因子:
11.3
通讯作者:
Filbey FM
Filbey FM
中科院分区:
医学2区
文献类型:
--
作者:
Feldstein Ewing SW;Mead HK;Yezhuvath U;Dewitt S;Hutchison KE;Filbey FM

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Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses wereunsupported, we found that the rs6311 C allelewas significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.
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