Expression of FSH receptor in the hamster ovary during perinatal development.
Expression of FSH receptor in the hamster ovary during perinatal development.
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DOI：
10.1016/j.mce.2014.11.014
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发表时间：
2015-01-15
影响因子：
4.1
通讯作者：
Roy SK
中科院分区：
文献类型：
--
作者：
Chakraborty P;Roy SK
FSH plays an important role in ovarian follicular development, and it functions via the G-protein coupled FSH receptor. The objectives of the present study were to determine if full-length FSHR mRNA and corresponding protein were expressed in fetal through postnatal hamster ovaries to explain the FSH-induced primordial follicle formation, and if FSH or estrogen (E) would affect the expression. A full-length and two alternately spliced FSHR transcripts were expressed from E14 through P20. The level of the full-length FSHR mRNA increased markedly through P7 before stabilizing at a lower level with the formation and activation of primordial follicles. A predicted 87kDa FSHR protein band was detected in fetal through P4 ovaries, but additional bands appeared as ovary developed. FSHR immunosignal was present in undifferentiated somatic cells and oocytes in early postnatal ovaries, but was granulosa cells specific after follicles formed. Both eCG and E significantly up-regulated full-length FSHR mRNA levels. Therefore, FSHR is expressed in the hamster ovary from the fetal life to account for FSH-induced primordial follicle formation and cAMP production. Further, FSH or E regulates the receptor expression.
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DOI：
10.1073/pnas.95.23.13612
发表时间：
1998-11-10
影响因子：
11.1
作者：
Dierich, A;Sairam, MR;Sassone-Corsi, P
通讯作者：
Sassone-Corsi, P
影响因子：
3.6
作者：
OShaughnessy, PJ;McLelland, D;McBride, MW
通讯作者：
McBride, MW
影响因子：
3.6
作者：
ROY, SK;HUGHES, J
通讯作者：
HUGHES, J
影响因子：
4.8
作者：
ERICKSON, GF;HSUEH, AJW
通讯作者：
HSUEH, AJW
影响因子：
4.8
作者：
McGee, E;Spears, N;Hsueh, AJW
通讯作者：
Hsueh, AJW