Seroepidemiology of human papillomavirus type 73: A sexually transmitted low‐risk virus
Seroepidemiology of human papillomavirus type 73: A sexually transmitted low‐risk virus
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73 型人乳头瘤病毒的血清流行病学：一种性传播低风险病毒
DOI：
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发表时间：
2000
影响因子：
6.4
通讯作者：
J. Dillner
中科院分区：
文献类型：
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作者：
K. Wallin;G. V. van Doornum;A. Andersson‐Ellström;I. Kallings;F. Wiklund;G. Hallmans;J. Schiller;J. Dillner
人乳头瘤病毒73型（HPV 73）已在一些浸润性宫颈癌中检测到，并已从食管鳞状细胞癌中克隆出来，但这种感染的流行病学及其相关的癌症风险尚不清楚。我们使用病毒样颗粒调查了该病毒的血清流行病学。对HPV 73的IgG反应似乎是HPV类型特异性的，因为比较HPV 6、11、16、18或33感染前后的HPV 73抗体水平，没有发现HPV 73抗体交叉诱导的证据，而且HPV 73抗体水平与其他5种研究的HPV类型之间几乎没有相关性。在一项包括274名女性的横断面血清调查和一项纳入98名女性的7年随访研究中，发现HPV 73血清阳性强烈依赖于终生性伴侣的数量[> 4对0至1伴侣的OR分别为：6.0（95%CI：1.4-53.6）和7.9（95%CI：2.8-28.3）]。最后，在一项前瞻性研究中，对15，234名瑞典妇女进行了HPV 73血清阳性妇女发生CIN的风险调查。在瑞典，基于人群的HPV 73血清阳性率为14%。未发现CIN的额外风险（OR：0.77）。我们的结论是，HPV 73主要是性传播的，可能大多是短暂的，感染，不赋予任何可测量的增加CIN发展的风险。Int. J. Cancer 85：353-357，2000.©2000 Wiley利斯公司
Human papillomavirus type 73 (HPV 73) has been detected in some invasive cervical cancers and has been cloned from a squamous‐cell carcinoma of the esophagus, but the epidemiology of this infection and its associated risk of cancer is unknown. We investigated the seroepidemiology of this virus using virus‐like particles. The IgG response to HPV 73 appeared to be HPV type‐specific, since a comparison of HPV 73 antibody levels before and after infection with HPV 6, 11, 16, 18 or 33 found no evidence of cross‐induction of HPV 73 antibodies and since there was little correlation between the antibody levels to HPV 73 and the other 5 investigated HPV types. In both a cross‐sectional serosurvey that included 274 women and a 7‐year follow‐up study that enrolled 98 women, HPV 73 seropositivity was found to be strongly dependent on the number of lifetime sexual partners [OR for > 4 vs. 0 to 1 partners: 6.0 (95%CI: 1.4–53.6) and 7.9 (95% CI: 2.8–28.3), respectively]. Finally, the risk for HPV 73 seropositive women to develop CIN was investigated in a prospective study nested in a cohort of 15,234 Swedish women. The population‐based HPV 73 seroprevalence in Sweden was 14%. No excess risk for CIN was found (OR: 0.77). We conclude that HPV 73 is a mainly sexually transmitted, probably mostly transient, infection that does not confer any measurably increased risk for CIN development. Int. J. Cancer 85:353–357, 2000. ©2000 Wiley‐Liss, Inc.
人乳头瘤病毒感染和食管癌：瑞典的一项全国性血清流行病学病例对照研究。
DOI：
10.1093/jnci/91.2.156
发表时间：
1999
期刊：
Journal of the National Cancer Institute
影响因子：
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作者：
Lagergren,J;Wang,Z;Bergström,R;Dillner,J;Nyrén,O
通讯作者：
Nyrén,O
DOI：
10.1093/jnci/86.7.494
发表时间：
1994-04-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Kirnbauer R;Hubbert NL;Wheeler CM;Becker TM;Lowy DR;Schiller JT
通讯作者：
Schiller JT